Xie Zi-Yi, Xuan Jun
Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials and Key Laboratory of Functional Inorganic Materials of Anhui Province, College of Chemistry & Chemical Engineering, Anhui University, Hefei, Anhui 230601, People's Republic of China.
Key Laboratory of Structure and Functional Regulation of Hybrid Materials, Anhui University, Ministry of Education, Hefei, Anhui 230601, People's Republic of China.
Chem Commun (Camb). 2024 Feb 20;60(16):2125-2136. doi: 10.1039/d3cc06056j.
Heterocyclic skeletons are commonly found in various bioactive molecules and pharmaceutical compounds, making them crucial in areas such as medicinal chemistry, materials science, and the realm of natural product synthesis. In recent years, the rapid advancements of visible light methodologies in organic synthesis have shown promising potential for the development of light-induced carbene transfer reactions. This is particularly significant as most organic molecules do not absorb visible light. Free carbene, known for its high activity, is frequently utilized for insertion reactions or cyclopropanation reactions. This review focuses on the photochemical strategy for the construction of heterocyclic skeletons, specifically highlighting the methods that employ visible light-promoted carbene transfer reactions.
杂环骨架常见于各种生物活性分子和药物化合物中，这使得它们在药物化学、材料科学和天然产物合成领域至关重要。近年来，可见光方法在有机合成中的快速发展为光诱导卡宾转移反应的开发显示出了有前景的潜力。这一点尤为重要，因为大多数有机分子不吸收可见光。以高活性著称的游离卡宾经常用于插入反应或环丙烷化反应。本综述重点关注构建杂环骨架的光化学策略，特别强调采用可见光促进卡宾转移反应的方法。
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