Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA.
Rood and Riddle Equine Hospital, Lexington, Kentucky, USA.
J Vet Intern Med. 2024 Mar-Apr;38(2):1196-1206. doi: 10.1111/jvim.16995. Epub 2024 Jan 29.
The neutrophil-lymphocyte ratio (NLR) in human medicine is an objective biomarker that reflects prognosis. The NLR as an independent biomarker to help predict nonsurvival in hospitalized neonatal foals has not been thoroughly interrogated.
OBJECTIVES/HYPOTHESIS: Retrospectively evaluate if the NLR at admission is associated with nonsurvival in sick hospitalized foals <4 days old. We hypothesized that a lower NLR will be associated with nonsurvival.
One thousand one hundred ninety-six client-owned foals <4 days old of any breed and sex: 993 hospitalized foals and 203 healthy foals.
Retrospective multicenter study. Medical records of foals presenting to 3 equine referral hospitals were reviewed. Foals were included if they had complete CBCs, sepsis scores, and outcome data. The NLR was calculated by dividing the absolute neutrophil count by the absolute lymphocyte count. Data were analyzed by nonparametric methods and univariate analysis.
Of the 993 sick hospitalized foals, 686 were sick nonseptic and 307 were septic. The median NLR was lower in sick hospitalized foals (median [95% confidence interval], 3.55 [0.5-13.9]) compared with healthy foals (6.61 [3.06-18.1]). Septic foals had the lowest NLR (2.00 [0.20-9.71]). The NLR was lower in nonsurviving (1.97 [1.67-2.45]) compared with surviving foals (4.10 [3.76-4.33]). Nonsurviving septic foals had the lowest NLR (1.47 [1.70-3.01]). Foals with a NLR of <3.06 or <1.6 at admission had odds ratio of 3.21 (2.24-4.29) and 4.03 (2.86-5.67) for nonsurvival, respectively.
A NLR < 3.06 at admission in sick hospitalized foals is readily available and clinically useful variable to provide prognostic information.
中性粒细胞与淋巴细胞比值（NLR）是反映预后的一种客观生物标志物。NLR 作为一种独立的生物标志物，可用于帮助预测住院新生驹的非存活情况，但尚未得到深入研究。
目的/假设：回顾性评估入院时的 NLR 是否与 4 日龄以下患病住院驹的非存活相关。我们假设 NLR 较低与非存活相关。
1196 匹患有疾病的客户所有驹，任何品种和性别：993 匹住院驹和 203 匹健康驹。
回顾性多中心研究。对 3 家马属动物转诊医院就诊的驹的病历进行了回顾。如果驹具有完整的全血细胞计数（CBC）、脓毒症评分和结局数据，则将其纳入研究。通过将绝对中性粒细胞计数除以绝对淋巴细胞计数来计算 NLR。使用非参数方法和单变量分析进行数据分析。
在 993 匹患病住院驹中，686 匹为患病非脓毒症驹，307 匹为脓毒症驹。与健康驹相比，患病住院驹的 NLR 中位数较低（中位数[95%置信区间]，3.55[0.5-13.9]）。脓毒症驹的 NLR 最低（2.00[0.20-9.71]）。与存活驹相比，非存活驹的 NLR 较低（1.97[1.67-2.45]）。非存活脓毒症驹的 NLR 最低（1.47[1.70-3.01]）。入院时 NLR<3.06 或 NLR<1.6 的驹，其非存活的比值比（OR）分别为 3.21（2.24-4.29）和 4.03（2.86-5.67）。
在患病住院驹中，入院时 NLR<3.06 是一种容易获得且具有临床意义的变量，可提供预后信息。
