Brynda E, Houska M, Novikova S P, Dobrova N B
Biomaterials. 1987 Jan;8(1):57-60. doi: 10.1016/0142-9612(87)90031-7.
Polyethylene blends with poly(2-hydroxyethyl methacrylate) [poly(HEMA)] or poly(2,3-dihydroxypropyl methacrylate) [poly(DHPMA)] were prepared by swelling polyethylene with HEMA or 2,3-epoxypropyl methacrylate (EPMA) and by polymerization of the respective monomers. Poly(EPMA) in blends was hydrolysed to poly(DHPMA) with acetic acid. The blends had similar surface and bulk compositions. Swelling with water and surface wettability were proportional to the content of the hydrophilic component; at the same content the polyethylene/poly(DHPMA) blends appeared more hydrophilic than those of polyethylene/poly(HEMA). Thrombus formation in contact with blood examined ex vivo and in vivo was considerably slower on the blends than on unmodified polyethylene. The tests indicated optima in composition; the best biological response was achieved with the blends containing about 14% poly(HEMA) or 16% poly(DHPMA).
通过用甲基丙烯酸2-羟乙酯（聚（HEMA））或甲基丙烯酸2,3-二羟丙酯（聚（DHPMA））溶胀聚乙烯，并使相应单体聚合，制备了聚乙烯与聚（甲基丙烯酸2-羟乙酯）[聚（HEMA）]或聚（甲基丙烯酸2,3-二羟丙酯）[聚（DHPMA）]的共混物。共混物中的聚（EPMA）用乙酸水解为聚（DHPMA）。这些共混物具有相似的表面和本体组成。用水溶胀和表面润湿性与亲水性组分的含量成正比；在相同含量下，聚乙烯/聚（DHPMA）共混物比聚乙烯/聚（HEMA）共混物显得更亲水。体外和体内与血液接触时血栓形成在共混物上比在未改性的聚乙烯上要慢得多。测试表明组成存在最佳值；含有约14%聚（HEMA）或16%聚（DHPMA）的共混物获得了最佳的生物学反应。
