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用于制药和生物医学科学中系统应用的新型脂质载体:综述

Emerging Lipid-based Carriers for Systematic Utilization in the Pharmaceutical and Biomedical Sciences: A Review.

作者信息

Kendre Prakash N, Kayande Dhiraj R, Pote Ajinkya K, Kanthale Sanagmeshwar B, Prajapati Bhupendra G, Kendre Yuvraj, Jain Shirish

机构信息

Rajarshi Shahu College of Pharmacy, Buldhana, 443001, Maharashtra, India.

Department of Pharmaceutics, Rajarshi Shahu College of Pharmacy, Khamgaon-Botha Road, Malvihir, Buldhana, 443001, India.

出版信息

Pharm Nanotechnol. 2025;13(1):2-21. doi: 10.2174/0122117385268268231204061938.


DOI:10.2174/0122117385268268231204061938
PMID:38284709
Abstract

Emerging lipid-based carriers are revolutionizing drug delivery in the pharmaceutical and biomedical sciences. These innovative carriers harness the unique properties of lipids to improve the solubility, stability, and targeted delivery of therapeutic agents, ushering in a new era of precision medicine. Lipid- based carriers, such as liposomes, lipid nanoparticles, and solid lipid nanoparticles, offer several advantages. They can encapsulate both hydrophilic and hydrophobic drugs, enabling the delivery of a wide range of compounds. Additionally, lipids are biocompatible and biodegradable, minimizing the risk of toxicity. Their ability to mimic cell membranes allows for enhanced cellular uptake and controlled release, optimizing drug efficacy while minimizing side effects. Furthermore, lipid-based carriers are ideal for delivering drugs to specific sites within the body. By modifying the lipid composition, surface charge, and size, researchers can tailor these carriers to target tumours, inflamed tissues, or specific cells, improving therapeutic outcomes and reducing systemic toxicity. In summary, emerging lipid-based carriers are poised to transform pharmaceutical and biomedical sciences by addressing critical challenges in drug delivery. These carriers enhance drug stability, bioavailability, and targeted delivery, offering the potential to revolutionize the treatment of various diseases and improve patient outcomes. As research in this field continues to advance, we can expect even more sophisticated lipid-based carrier systems to emerge, further expanding the possibilities for precision medicine. This review focuses on the contribution of lipid carriers in the pharmaceutical and biomedical sciences.

摘要

新型脂质载体正在彻底改变制药和生物医学领域的药物递送方式。这些创新型载体利用脂质的独特性质来提高治疗药物的溶解度、稳定性和靶向递送能力,开创了精准医学的新时代。脂质载体,如脂质体、脂质纳米颗粒和固体脂质纳米颗粒,具有多种优势。它们能够包封亲水性和疏水性药物,从而实现多种化合物的递送。此外,脂质具有生物相容性和可生物降解性,可将毒性风险降至最低。它们模拟细胞膜的能力使得细胞摄取增强且释放可控,在将副作用降至最低的同时优化了药物疗效。此外,脂质载体是将药物递送至体内特定部位的理想选择。通过改变脂质组成、表面电荷和大小,研究人员可以对这些载体进行定制,使其靶向肿瘤、炎症组织或特定细胞,改善治疗效果并降低全身毒性。总之,新型脂质载体有望通过应对药物递送中的关键挑战来变革制药和生物医学领域。这些载体增强了药物稳定性、生物利用度和靶向递送能力,为彻底改变各种疾病的治疗方式并改善患者预后提供了潜力。随着该领域研究的不断推进,我们可以期待出现更复杂的脂质载体系统,进一步拓展精准医学的可能性。本综述重点关注脂质载体在制药和生物医学领域的贡献。

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本文引用的文献

[1]
Chloroform-Injection (CI) and Spontaneous-Phase-Transition (SPT) Are Novel Methods, Simplifying the Fabrication of Liposomes with Versatile Solution to Cholesterol Content and Size Distribution.

Pharmaceutics. 2020-11-9

[2]
Exploiting the Natural Properties of Extracellular Vesicles in Targeted Delivery towards Specific Cells and Tissues.

Pharmaceutics. 2020-10-26

[3]
Continuous-Flow Production of Liposomes with a Millireactor under Varying Fluidic Conditions.

Pharmaceutics. 2020-10-22

[4]
Liposomes Co-Encapsulating Cisplatin/Mifepristone Improve the Effect on Cervical Cancer: In Vitro and In Vivo Assessment.

Pharmaceutics. 2020-9-22

[5]
Rapid scale-up and production of active-loaded PEGylated liposomes.

Int J Pharm. 2020-8-30

[6]
Biomimetic Magnetoliposomes as Oxaliplatin Nanocarriers: In Vitro Study for Potential Application in Colon Cancer.

Pharmaceutics. 2020-6-24

[7]
Solid lipid nanoparticles: a review on recent perspectives and patents.

Expert Opin Ther Pat. 2020-1-31

[8]
Solid lipid nanoparticles self-assembled from spray dried microparticles.

Int J Pharm. 2019-10-30

[9]
Targeted co-delivery of protein and drug to a tumor in vivo by sophisticated RGD-modified lipid-calcium carbonate nanoparticles.

J Control Release. 2019-3-26

[10]
Efficient gene transfection to the brain with ultrasound irradiation in mice using stabilized bubble lipopolyplexes prepared by the surface charge regulation method.

Int J Nanomedicine. 2018-4-16

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