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孤立性大量胸腔积液作为慢性移植物抗宿主病的表现，经皮质类固醇治疗后成功缓解。

Isolated massive pleural effusion as a manifestation of chronic graft versus host disease successfully treated with corticosteroid.

机构信息

Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.

Department of Cell Therapy and Transplantation Medicine, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.

出版信息

Ann Hematol. 2024 Apr;103(4):1403-1407. doi: 10.1007/s00277-024-05643-w. Epub 2024 Jan 29.

DOI:10.1007/s00277-024-05643-w
PMID:38285080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10940441/
Abstract

Isolated pleural effusion is a rare manifestation of chronic graft versus host disease (cGVHD) after hematopoietic stem cell transplantation (HSCT). We herein report a 58-year-old woman presenting with massive pleural effusion approximately 1 year after allogeneic HSCT, who was successfully treated with corticosteroid. She had discontinued tacrolimus approximately 1 month before she presented with pleural effusion, which was attributed to cGVHD after a thorough exclusion process. This case illustrates a unique manifestation of atypical cGVHD and highlights the need for prompt therapy initiation.

摘要

孤立性胸腔积液是造血干细胞移植（HSCT）后慢性移植物抗宿主病（cGVHD）的罕见表现。本研究报告了一例 58 岁女性，在异基因 HSCT 后约 1 年出现大量胸腔积液，经皮质类固醇治疗后成功治愈。她在出现胸腔积液前约 1 个月停用了他克莫司，经彻底排除过程后归因于 cGVHD。该病例说明了非典型 cGVHD 的一种独特表现，并强调了及时开始治疗的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa6b/10940441/c343cb81ac25/277_2024_5643_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa6b/10940441/c94cfd520167/277_2024_5643_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa6b/10940441/c343cb81ac25/277_2024_5643_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa6b/10940441/c94cfd520167/277_2024_5643_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa6b/10940441/c343cb81ac25/277_2024_5643_Fig2_HTML.jpg

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本文引用的文献

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Toward a Better Understanding of the Atypical Features of Chronic Graft-Versus-Host Disease: A Report from the 2020 National Institutes of Health Consensus Project Task Force.旨在更好地理解慢性移植物抗宿主病的非典型特征：来自 2020 年美国国立卫生研究院共识项目工作组的报告。
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异基因造血干细胞移植中胸腔积液的发病率、病因及转归
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