Simonian M A, Gevorkian D M, Mkhitarian V G
Biull Eksp Biol Med. 1987 Mar;103(3):306-8.
The contents of Cu, Zn-superoxide dismutase and catalase isolated and purified from the rat liver at the terminal stages of alloxan diabetes were decreased by 40% and 15%, respectively, as compared to the control. It can be concluded that the decrease in superoxide dismutase and catalase activity in experimental alloxan diabetes is mainly connected with the decline in the content of these proteins at the terminal stages of the disease, this, probably, being the result of DNA degradation and RNA transport disturbances under the effect of oxygen active forms.
与对照组相比，从四氧嘧啶糖尿病大鼠肝脏分离纯化的铜锌超氧化物歧化酶和过氧化氢酶的含量在疾病终末期分别降低了40%和15%。可以得出结论，实验性四氧嘧啶糖尿病中超氧化物歧化酶和过氧化氢酶活性的降低主要与疾病终末期这些蛋白质含量的下降有关，这可能是氧活性形式作用下DNA降解和RNA转运紊乱的结果。
