From the Departments of Dermatology, Duke University Medical Center, Durham, North Carolina, USA.
Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina, USA.
Dermatitis. 2024 Jul-Aug;35(4):366-372. doi: 10.1089/derm.2023.0310. Epub 2024 Jan 29.
Supplemental patch testing is an adjunct to standard patch test screening series. To determine the demographics, characteristics, frequency, relevance, and interpretation of patch test reactions for supplemental patch testing. Retrospective study of patients tested 2017-2020 with North American Contact Dermatitis Group (NACDG) and supplemental screening series (Supplemental Series A [SSA], Supplemental Series B [SSB]). Demographics, characteristics, reaction strengths, relevance, and final interpretation were recorded. Cohort included 791 patients; 73.5% female, 68.6% age >40 years. 74.1% were White, 15.2% Black, 5.7% Asian, and 1.5% Hispanic. The most common Dermatitis sites were scattered/generalized (27.2%), face (24.0%), and hands (23.5%). For 2017-2018 and 2019-2020, respectively, 82% (318/388) and 78.4% (316/403) had ≥1 "allergic" reaction. In addition, 13.5% (52/385) and 11.7% (47/403) had SSA reactions, and 38.1% (115/302) and 31.5% (101/321) had SSB reactions. In the 87 (2017-2018) and 99 (2019-2020) patients with negative NACDG testing, 17 (19.5%) and 12 (12.1%) had supplemental reactions. Of the 34 supplemental allergens with reaction frequency ≥1%, 58.8% (20/34) are not part of the American Contact Dermatitis Society 90 (2020) or NACDG 2021-2022 screening series. The highest frequency allergens from this group were dodecyl and octyl gallate, cinnamic alcohol, phenyl salicylate, hexahydro-1,3,5-tris-(2-hydroxyethyl) triazine, and abitol. Supplemental patch testing identifies additional relevant allergens in patients with suspected allergic contact Dermatitis.
补充斑贴试验是标准斑贴试验筛查系列的辅助手段。为了确定补充斑贴试验的患者人群、特征、频率、相关性和斑贴试验反应的解释。回顾性研究了 2017-2020 年接受北美接触性皮炎组（NACDG）和补充筛查系列（补充系列 A[SSA]、补充系列 B[SSB]）检测的患者。记录了患者的人口统计学、特征、反应强度、相关性和最终解释。队列包括 791 名患者；73.5%为女性，68.6%年龄>40 岁。74.1%为白人，15.2%为黑人，5.7%为亚洲人，1.5%为西班牙裔。最常见的皮炎部位是散在/全身性（27.2%）、面部（24.0%）和手部（23.5%）。对于 2017-2018 年和 2019-2020 年，分别有 82%（318/388）和 78.4%（316/403）有≥1 个“过敏”反应。此外，13.5%（52/385）和 11.7%（47/403）有 SSA 反应，38.1%（115/302）和 31.5%（101/321）有 SSB 反应。在 NACDG 检测阴性的 87 名（2017-2018 年）和 99 名（2019-2020 年）患者中，有 17 名（19.5%）和 12 名（12.1%）有补充反应。在反应频率≥1%的 34 种补充变应原中，58.8%（20/34）不属于美国接触性皮炎学会 90 项（2020 年）或 NACDG 2021-2022 筛查系列。该组中频率最高的变应原是十二烷基和辛基没食子酸酯、肉桂醇、水杨酸苯酯、六氢-1,3,5-三（2-羟乙基）三嗪和阿比妥。补充斑贴试验可在疑似过敏性接触性皮炎患者中识别出其他相关变应原。
