Goodyear Kendall, Ghiam Sean, Strawbridge Jason, Oh Angela J, Singh Pallavi, Roelofs Kelsey A, Rootman Daniel B
Department of Ophthalmology, Division of Orbital and Ophthalmic Plastic Surgery, Jules Stein Eye Institute, University of California, Los Angeles, California, U.S.A.
Department of Ophthalmology, Sackler School of Medicine, New York State/American Program of Tel Aviv University, Tel Aviv, Israel.
Ophthalmic Plast Reconstr Surg. 2024;40(4):399-402. doi: 10.1097/IOP.0000000000002592. Epub 2024 Jan 25.
To determine the prevalence, clinical features, and radiographic findings of superior ophthalmic vein periphlebitis (SOVP) in thyroid eye disease (TED).
Patients with a clinical diagnosis of thyroid eye disease and contrast-enhanced imaging were included. Imaging was reviewed for the presence of SOVP, and patients with SOVP were compared to those without. A random eye was determined to be the affected eye in patients without SOVP.
A total of 212 patients met the inclusion criteria. Unilateral SOVP was identified in 4.7% of cases. There was no significant difference in age ( p = 0.22), gender ( p = 0.09), or disease duration ( p = 0.14) between patients with and without SOVP. There was a significant ( p < 0.05) difference in stage classification and clinical activity core between the groups. The affected eye in patients with SOVP had significantly ( p < 0.05) greater margin reflex distance 1, degree of relative proptosis, horizontal motility restriction, and vertical motility restriction than in patients without SOVP. There was no significant difference in horizontal strabismus ( p = 1.0), vertical strabismus ( p = 0.87), or relative intraocular pressure ( p = 0.77). On imaging, the maximal diameter of the SR and IR were found to be significantly ( p < 0.05) larger in the affected eye of patients with periphlebitis; however, there was no difference in measured diameter of the medial rectus and ( p = 0.30) or lateral rectus ( p = 0.78).
SOVP is an under-reported imaging finding of thyroid eye disease. It is associated with significantly greater margin reflex distance 1, relative proptosis, and motility restriction on exam as well as larger superior rectus and inferior rectus diameter on imaging. These patients tend to present in the active stage of disease with greater clinical activity score.
确定甲状腺眼病（TED）中眼上静脉周围炎（SOVP）的患病率、临床特征及影像学表现。
纳入临床诊断为甲状腺眼病且行增强成像的患者。对影像学检查进行评估，以确定是否存在SOVP，并将存在SOVP的患者与不存在SOVP的患者进行比较。对于不存在SOVP的患者，随机选择一只眼作为患眼。
共有212例患者符合纳入标准。4.7%的病例中发现单侧SOVP。存在SOVP与不存在SOVP的患者在年龄（p = 0.22）、性别（p = 0.09）或病程（p = 0.14）方面无显著差异。两组在分期分类和临床活动核心方面存在显著（p < 0.05）差异。与不存在SOVP的患者相比，存在SOVP的患者患眼的边缘反射距离1、相对突眼度、水平运动受限和垂直运动受限显著（p < 0.05）更大。水平斜视（p = 1.0）、垂直斜视（p = 0.87）或相对眼压（p = 0.77）方面无显著差异。在影像学上，静脉周围炎患者患眼的上直肌和下直肌最大直径显著（p < 0.05）更大；然而，内直肌（p = 0.30）和外直肌（p = 0.78）的测量直径无差异。
SOVP是甲状腺眼病中报告较少的影像学表现。它与检查时显著更大的边缘反射距离1、相对突眼度和运动受限以及影像学上更大的上直肌和下直肌直径相关。这些患者往往在疾病的活动期出现，临床活动评分更高。
