Hospital de Clínicas de Porto Alegre/HCPA.
Hospital de Clínicas de Porto Alegre/HCPA.
Transpl Immunol. 2024 Apr;83:102002. doi: 10.1016/j.trim.2024.102002. Epub 2024 Jan 28.
Hematopoietic Stem Cell Transplant (HSCT) is currently an important curative treatment for many patients with malignant and non-malignant diseases. Graft versus host disease (GVHD) represents a major complication in allogeneic HSCT recipients. Several polymorphisms in cytokine genes have recently been investigated as candidates for risk factors for acute-GVHD (aGVHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT).
In this study, we analyzed specific interleukin (IL)-10 haplotypes polymorphisms, in a cohort of 99 patients and their respective allo-HSCT donors for aGVHD and risk.
An association was found between IL-10 promoter haplotype polymorphisms at positions -1082, -819 and - 592 with the occurrence of aGVHD. Patients who have the GCC/GCC haplotype are at increased risk of aGVHD (P = 0.017, HR: 5.42 (95% CI: 1.34-21.84). In the donors group and severity of aGVHD as not found statistical significancy.
The results obtained show the IL-10 GCC/GCC haplotype can be an important biomarker to identify the greatest risk of aGVHD in the patient undergoing HSCT.
造血干细胞移植（HSCT）目前是治疗许多恶性和非恶性疾病患者的重要治疗方法。移植物抗宿主病（GVHD）是异基因 HSCT 受者的主要并发症。最近，细胞因子基因中的几种多态性被认为是异基因造血干细胞移植（allo-HSCT）中急性移植物抗宿主病（aGVHD）的危险因素。
在本研究中，我们分析了 99 例患者及其各自的 allo-HSCT 供体中特定白细胞介素（IL）-10 单倍型多态性与 aGVHD 和风险的关系。
在 IL-10 启动子位置-1082、-819 和-592 的单倍型多态性与 aGVHD 的发生之间存在关联。具有 GCC/GCC 单倍型的患者发生 aGVHD 的风险增加（P=0.017，HR：5.42（95%CI：1.34-21.84）。在供体组中，aGVHD 的严重程度未发现统计学意义。
所得结果表明，IL-10 GCC/GCC 单倍型可作为识别 HSCT 患者发生 aGVHD 最大风险的重要生物标志物。
