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大鼠嗅觉跨度任务中新颖性奖励交叉提示的证据:对基于气味的奖励动机任务的启示。

Evidence for novelty reward cross-cueing in the odor span task in rats: implications for odor-based reward-motivated tasks.

机构信息

Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada.

Department of Anatomy, Physiology, and Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada

出版信息

Learn Mem. 2024 Jan 29;31(1-2). doi: 10.1101/lm.053871.123. Print 2024 Jan-Feb.

Abstract

The odor span task (OST) infers working memory capacity (WMC) by requiring rodents to discriminate between previously presented and session-novel odors to obtain a hidden food reward. Here, rats' responses to session-novel odors and food rewards were assessed to determine whether rats use mitigating strategies in the OST. Rats accurately responded to session-novel odors but also reliably responded to the food reward alone and performed at chance when both a session-novel odor and food reward were presented in separate locations. The inclusion of unscented sand in the cups holding the food reward significantly reduced the rats' responses to the food reward alone. Collectively, these results demonstrate the need for rigorous tests of potential mitigating strategies and hold wide implications for rodent odor discrimination-based behavioral tasks.

摘要

气味跨度任务(OST)通过要求啮齿动物辨别先前呈现的和当前新颖的气味来获得隐藏的食物奖励,从而推断出工作记忆容量(WMC)。在这里,评估了大鼠对当前新颖气味和食物奖励的反应,以确定大鼠在 OST 中是否使用了缓解策略。大鼠准确地对当前新颖的气味做出反应,但也可靠地对单独的食物奖励做出反应,并且当在单独的位置呈现当前新颖的气味和食物奖励时,其表现出机会水平。在装有食物奖励的杯子中加入无味的沙子会显著减少大鼠对单独的食物奖励的反应。总的来说,这些结果表明需要对潜在缓解策略进行严格的测试,并且对基于啮齿动物气味辨别行为任务具有广泛的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a639/10903935/433e2db582a7/LM053871Ono_F1.jpg

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