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解锁“卵母细胞”潜能:免疫疗法在塑造卵巢癌治疗未来中的作用。

Unlocking the 'ova'-coming power: immunotherapy's role in shaping the future of ovarian cancer treatment.

机构信息

Department of Microbiology, Immunology & Pathology, Des Moines University College of Osteopathic Medicine, 8025, Grand Ave, West Des Moines, IA, 50266, USA.

Department of Surgery, University of Missouri School of Medicine, Columbia, MO, 65212, USA.

出版信息

Med Oncol. 2024 Jan 29;41(3):67. doi: 10.1007/s12032-023-02281-6.


DOI:10.1007/s12032-023-02281-6
PMID:38286890
Abstract

Ovarian cancer is a prominent cancer worldwide with a relatively low survival rate for women diagnosed. Many individuals are diagnosed in the late stage of the disease and are prescribed a wide variety of treatment options. Current treatment options are primarily a combination of surgery and chemotherapy as well as a new but promising treatment involving immunotherapy. Nevertheless, contemporary therapeutic modalities exhibit a discernible lag in advancement when compared with the strides achieved in recent years in the context of other malignancies. Moreover, many surgery and chemotherapy options have a high risk for recurrence due to the late-stage diagnosis. Therefore, there is a necessity to further treatment options. There have been many new advancements in the field of immunotherapy. Immunotherapy has been approved for 16 various types of cancers and has shown significant treatment potential in many other cancers as well. Researchers have also found many promising outlooks for immunotherapy as a treatment for ovarian cancer. This review summarizes many of the new advancements in immunotherapy treatment options and could potentially offer valuable insights to gynecologists aimed at enhancing the efficacy of their treatment approaches for patients diagnosed with ovarian cancer.

摘要

卵巢癌是一种全球范围内显著的癌症,女性患者的生存率相对较低。许多患者在疾病晚期被诊断出来,并被开处了各种各样的治疗方案。目前的治疗方案主要是手术和化疗的结合,以及一种新的但有前途的免疫疗法。然而,与近年来在其他恶性肿瘤方面取得的进展相比,当代治疗方法的进展明显滞后。此外,由于晚期诊断,许多手术和化疗方案的复发风险很高。因此,有必要进一步探索治疗方案。免疫疗法领域有许多新的进展。免疫疗法已经批准用于 16 种不同类型的癌症,并在许多其他癌症中显示出显著的治疗潜力。研究人员还发现了免疫疗法作为卵巢癌治疗方法的许多有前景的展望。这篇综述总结了免疫疗法治疗方案的许多新进展,可能为妇科医生提供有价值的见解,旨在提高他们对卵巢癌患者治疗方法的疗效。

相似文献

[1]
Unlocking the 'ova'-coming power: immunotherapy's role in shaping the future of ovarian cancer treatment.

Med Oncol. 2024-1-29

[2]
Cellular immunotherapy in ovarian cancer: Targeting the stem of recurrence.

Gynecol Oncol. 2015-5

[3]
Immunotherapy for Ovarian Cancer: Disappointing or Promising?

Mol Pharm. 2024-2-5

[4]
The past, present, and future of immunotherapy for bladder tumors.

Med Oncol. 2022-9-29

[5]
New Approaches for Immune Directed Treatment for Ovarian Cancer.

Curr Treat Options Oncol. 2016-3

[6]
Immunotherapy in Ovarian Cancer.

Arch Immunol Ther Exp (Warsz). 2022-8-9

[7]
Leveraging epigenetics to enhance the efficacy of cancer-testis antigen: a potential candidate for immunotherapy.

Epigenomics. 2022-7

[8]
Combination therapy with B7H3-redirected bispecific antibody and Sorafenib elicits enhanced synergistic antitumor efficacy.

Theranostics. 2020

[9]
Effect of neoadjuvant chemotherapy on the immune microenvironment of gynaecological tumours.

Ann Med. 2023

[10]
Immunotherapy for recurrent ovarian cancer: a further piece of the puzzle or a striking strategy?

Expert Opin Biol Ther. 2014-1

引用本文的文献

[1]
Management of Advanced Ovarian Cancer: Current Clinical Practice and Future Perspectives.

Biomedicines. 2025-6-22

[2]
Unraveling the role of M2 TAMs in ovarian cancer dynamics: a systematic review.

J Transl Med. 2025-6-3

本文引用的文献

[1]
Cancer vaccines as promising immuno-therapeutics: platforms and current progress.

J Hematol Oncol. 2022-3-18

[2]
Establishment and Verification of Logistic Regression Model for Qualitative Diagnosis of Ovarian Cancer Based on MRI and Ultrasound Signs.

Comput Math Methods Med. 2022

[3]
The role of CT, PET-CT, and MRI in ovarian cancer.

Br J Radiol. 2021-9-1

[4]
Multimodal Treatment of Primary Advanced Ovarian Cancer.

Anticancer Res. 2021-7

[5]
Ovarian Cancer Immunotherapy and Personalized Medicine.

Int J Mol Sci. 2021-6-18

[6]
Natural killer T cell immunotherapy combined with oncolytic vesicular stomatitis virus or reovirus treatments differentially increases survival in mouse models of ovarian and breast cancer metastasis.

J Immunother Cancer. 2021-3

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Cytokine engineering for targeted cancer immunotherapy.

Curr Opin Chem Biol. 2021-6

[8]
Dendritic Cell Vaccines in Ovarian Cancer.

Front Immunol. 2020

[9]
Pegylated liposomal doxorubicin in patients with epithelial ovarian cancer.

J Ovarian Res. 2021-1-11

[10]
IL-15 superagonist N-803 improves IFNγ production and killing of leukemia and ovarian cancer cells by CD34 progenitor-derived NK cells.

Cancer Immunol Immunother. 2021-5

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