血清尿酸水平与 NHANES 队列（2007-2012 年）肺功能的关系：对美国不同人群的横断面分析。

Association between serum uric acid levels and lung function in the NHANES cohort (2007-2012): A cross-sectional analysis of a diverse American population.

机构信息

Department of Rheumatism, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.

出版信息

Int J Rheum Dis. 2024 Jan;27(1):e15043. doi: 10.1111/1756-185X.15043.

DOI:10.1111/1756-185X.15043

PMID:38287539

Abstract

BACKGROUND

Hyperuricemia has been linked to various health conditions. However, the relationship between uric acid (UA) levels and lung function remains debated.

METHODS

In a cross-sectional study of 6750 participants aged 20-69 from NHANES, we assessed UA levels and lung function (FVC and FEV1). We conducted regression analyses while adjusting for potential confounders.

RESULTS

After accounting for factors like age, sex, BMI, smoking, and more, we found a negative association between UA FVC and FEV1. Specifically, for every 0.1 mg/dL increase in UA, FEV1 decreased by 15.265 mL, and FVC decreased by 24.46 mL. No association was observed with FEV1/FVC. Subgroup analyses revealed similar negative correlations among various groups, particularly in non-Hispanic Black females under 60.

CONCLUSION

Serum UA levels are inversely associated with FEV1 and FVC in the American population, with a notable impact on non-Hispanic Black females under 60.

摘要

背景

高尿酸血症与各种健康状况有关。然而，尿酸（UA）水平与肺功能之间的关系仍存在争议。

方法

在 NHANES 中对 6750 名 20-69 岁的参与者进行了一项横断面研究，我们评估了 UA 水平和肺功能（FVC 和 FEV1）。我们进行了回归分析，同时调整了潜在的混杂因素。

结果

在考虑了年龄、性别、BMI、吸烟等因素后，我们发现 UA 与 FVC 和 FEV1 之间呈负相关。具体而言，UA 每增加 0.1mg/dL，FEV1 降低 15.265mL，FVC 降低 24.46mL。FEV1/FVC 与 UA 无关联。亚组分析显示，在各个组中均观察到类似的负相关，尤其是在 60 岁以下的非西班牙裔黑人女性中。