Song Jae-Uk, Hwang Jiwon, Ahn Joong Kyong
a Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital , Sungkyunkwan University School of Medicine , Seoul , South Korea.
b Division of Rheumatology, Department of Internal Medicine , National Police Hospital , Seoul , South Korea.
Mod Rheumatol. 2017 Nov;27(6):1057-1065. doi: 10.1080/14397595.2017.1285981. Epub 2017 Feb 21.
To determine whether level of serum uric acid (SUA) is linked to pulmonary function in health screening examinees without overt medical conditions.
We performed a cross-sectional study on 69,928 Koreans that participated in an annual health check.
Percent predicted forced vital capacity (FVC%) and forced expiratory volume in 1 s (FEV1%) were positively correlated with SUA in both genders (FVC%: r = .361; FEV1%: r = .314 in males and FVC%: r = .413; FEV1%: r = .382 in females, all p < .001). When the 2nd, 3rd and lowest FEV1% quartile were compared to the highest quartile group (the reference) by regression analysis, the adjusted ORs for hyperuricemia in males were 0.876 (95% CI, 0.809-0.949), 0.631 (0.574-0.695), and 0.311 (0.278-0.349), respectively. The adjusted ORs for hyperuricemia when the 2nd, 3rd and lowest FEV1% quartile were compared to the highest quartile in males were 0.791 (95% CI, 0.729-0.859), 0.565 (0.513-0.623), and 0.302 (0.270-0.337), respectively (p for trend <.001). Similarly, the adjusted OR of having hyperuricemia in females decreased significantly across FEV1% and FVC% quartile groups compared to the reference.
Hyperuricemia may have a positive effect on pulmonary function in middle aged healthy population.
确定在无明显疾病的健康筛查受检者中，血清尿酸（SUA）水平是否与肺功能相关。
我们对69928名参加年度健康检查的韩国人进行了一项横断面研究。
预计用力肺活量百分比（FVC%）和第1秒用力呼气量百分比（FEV1%）在两性中均与SUA呈正相关（男性FVC%：r = 0.361；FEV1%：r = 0.314，女性FVC%：r = 0.413；FEV1%：r = 0.382，所有p < 0.001）。通过回归分析将第二、第三和最低FEV1%四分位数组与最高四分位数组（参照组）进行比较时，男性高尿酸血症的校正比值比分别为0.876（95%可信区间，0.809 - 0.949）、0.631（0.574 - 0.695）和0.311（0.278 - 0.349）。男性中当将第二、第三和最低FEV1%四分位数组与最高四分位数组进行比较时，高尿酸血症的校正比值比分别为0.791（95%可信区间，0.729 - 0.859）、0.565（0.513 - 0.623）和0.302（0.270 - 0.337）（趋势p < 0.001）。同样，与参照组相比，女性中高尿酸血症的校正比值比在FEV1%和FVC%四分位数组中显著降低。
高尿酸血症可能对中年健康人群的肺功能有积极影响。
