Laudon M, Zisapel N
Brain Res. 1987 Jan 27;402(1):146-50. doi: 10.1016/0006-8993(87)91057-2.
The distribution of 125I-melatonin binding sites in 6 discrete brain regions of female rats at the estrous stage and the effects of ovariectomy and subsequent 17 beta-estradiol treatment on these binding sites were studied. Specific binding of 125I-melatonin was found in the hypothalamus, medulla-pons, hippocampus, cerebellum, striatum and parietal cortex of the female rats. Ovariectomy produced a large estradiol-reversible decrease in 125I-melatonin binding in the medulla-pons and hypothalamus. In contrast, 125I-melatonin binding sites in the other brain regions were generally unaffected by ovariectomy or estradiol. The estradiol-regulated changes in melatonin binding in the hypothalamus and medulla-pons may reflect the role of a specific estradiol-melatonin interaction in the coordination of the neuroendocrine reproductive axis.
研究了动情期雌性大鼠6个离散脑区中125I-褪黑素结合位点的分布，以及卵巢切除和随后的17β-雌二醇处理对这些结合位点的影响。在雌性大鼠的下丘脑、延髓-脑桥、海马、小脑、纹状体和顶叶皮质中发现了125I-褪黑素的特异性结合。卵巢切除导致延髓-脑桥和下丘脑中125I-褪黑素结合大幅下降，且这种下降可被雌二醇逆转。相比之下，其他脑区的125I-褪黑素结合位点通常不受卵巢切除或雌二醇的影响。下丘脑和延髓-脑桥中褪黑素结合的雌二醇调节变化可能反映了特定的雌二醇-褪黑素相互作用在神经内分泌生殖轴协调中的作用。
