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探索咪唑并哒嗪类药物尚未开发的药理潜力。

Exploring the untapped pharmacological potential of imidazopyridazines.

作者信息

Malik M Shaheer, Alshareef Hossa F, Alfaidi Khalid A, Ather Hissana, Abduljaleel Zainularifeen, Hussein Essam M, Moussa Ziad, Ahmed Saleh A

机构信息

Department of Chemistry, Faculty of Science, Umm Al-Qura University Makkah 21955 Saudi Arabia.

Science and Technology Unit, Umm Al-Qura University Makkah 21955 Saudi Arabia.

出版信息

RSC Adv. 2024 Jan 29;14(6):3972-3984. doi: 10.1039/d3ra07280k. eCollection 2024 Jan 23.

DOI:10.1039/d3ra07280k
PMID:38288152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10823362/
Abstract

Imidazopyridazines are fused heterocycles, like purines, with a pyridazine ring replacing the pyrimidine ring in purines. Imidazopyridazines have been primarily studied for their kinase inhibition activity in the development of new anticancer and antimalarial agents. In addition to this, they have also been investigated for their anticonvulsant, antiallergic, antihistamine, antiviral, and antitubercular properties. Herein, we review the background and development of different imidazopyridazines as potential pharmacological agents. Moreover, the scope of this relatively less charted heterocyclic scaffold is also highlighted.

摘要

咪唑并哒嗪类是稠合杂环，与嘌呤类似，其中哒嗪环取代了嘌呤中的嘧啶环。在新型抗癌和抗疟药物的研发中，咪唑并哒嗪类主要因其激酶抑制活性而受到研究。除此之外，它们还因其抗惊厥、抗过敏、抗组胺、抗病毒和抗结核特性而得到研究。在此，我们综述了不同咪唑并哒嗪类作为潜在药理剂的背景和发展。此外，还突出了这个相对较少被研究的杂环骨架的研究范围。

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Imidazopyridazine Acetylcholinesterase Inhibitors Display Potent Anti-Proliferative Effects in the Human Neuroblastoma Cell-Line, IMR-32.咪唑并吡啶乙酰胆碱酯酶抑制剂在人神经母细胞瘤细胞系 IMR-32 中显示出很强的抗增殖作用。
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