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[羟氯喹——用于皮肤科非标签用药并非总是无害的药物]

[Hydroxychloroquine-not always a harmless drug for off label use in dermatology].

作者信息

Seidel Paloma, Spukti Eva, Steinbrink Kerstin, Metze Dieter, Böhm Markus

机构信息

Klinik für Hautkrankheiten, Universitätsklinikum Münster, Von-Esmarch-Str. 58, 48149, Münster, Deutschland.

出版信息

Dermatologie (Heidelb). 2024 May;75(5):412-415. doi: 10.1007/s00105-024-05294-y. Epub 2024 Jan 30.

DOI:10.1007/s00105-024-05294-y
PMID:38289364
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11065929/
Abstract

Hydroxychloroquine is used for treatment of inflammatory diseases. It is considered to have few adverse effects. We report on a woman who developed a severe skin rash after intake of hydroxychloroquine, which she received for treatment of her lichen planopilaris. Based on the clinical, laboratory and histological findings the diagnosis of a drug reaction with eosinophilia and systemic symptoms (DRESS)-like drug reaction was established. Our case illustrates that hydroxychloroquine can lead to severe adverse effects in rare cases and that patients receiving this drug must be thoroughly informed.

摘要

羟氯喹用于治疗炎症性疾病。它被认为不良反应较少。我们报告了一名女性，她在服用羟氯喹治疗扁平苔藓性毛发角化病后出现了严重皮疹。根据临床、实验室和组织学检查结果，确诊为伴有嗜酸性粒细胞增多和全身症状的药物反应（DRESS）样药物反应。我们的病例表明，羟氯喹在罕见情况下可导致严重不良反应，必须让接受该药物治疗的患者充分了解这一点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/562b/11065929/b51cba0c9470/105_2024_5294_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/562b/11065929/16c077ab4c18/105_2024_5294_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/562b/11065929/b51cba0c9470/105_2024_5294_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/562b/11065929/16c077ab4c18/105_2024_5294_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/562b/11065929/b51cba0c9470/105_2024_5294_Fig2_HTML.jpg

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本文引用的文献

1
Use of hydroxychloroquine and azithromycin combination to treat the COVID-19 infection.使用羟氯喹和阿奇霉素联合治疗新冠病毒感染。
World J Exp Med. 2022 May 20;12(3):44-52. doi: 10.5493/wjem.v12.i3.44.
2
Drug Reaction with Eosinophilia and Systemic Symptoms (DReSS)/Drug-Induced Hypersensitivity Syndrome (DiHS)-Readdressing the DReSS.伴嗜酸性粒细胞增多和全身症状的药物反应（DReSS）/药物性超敏反应综合征（DiHS）——重新审视DReSS
Biomedicines. 2022 Apr 26;10(5):999. doi: 10.3390/biomedicines10050999.
3
Drug-Induced Hypersensitivity Syndrome (DIHS)/Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS): Clinical Features and Pathogenesis.
药物诱导的超敏反应综合征（DIHS）/伴嗜酸性粒细胞增多和全身症状的药物反应（DRESS）：临床特征和发病机制。
J Allergy Clin Immunol Pract. 2022 May;10(5):1155-1167.e5. doi: 10.1016/j.jaip.2022.02.004. Epub 2022 Feb 15.
4
Updates and Insights in the Diagnosis and Management of DRESS Syndrome.药物超敏反应综合征诊断与管理的最新进展与见解
Curr Dermatol Rep. 2021;10(4):192-204. doi: 10.1007/s13671-021-00348-z. Epub 2021 Nov 9.
5
Hydroxychloroquine: a comprehensive review and its controversial role in coronavirus disease 2019.羟氯喹：全面综述及其在 2019 冠状病毒病中的争议性作用。
Ann Med. 2021 Dec;53(1):117-134. doi: 10.1080/07853890.2020.1839959.
6
Generalized pustular figurate erythema: A newly delineated severe cutaneous drug reaction linked with hydroxychloroquine.泛发性脓疱状图状红斑：一种与羟氯喹相关的新划定的严重皮肤药物反应。
Dermatol Ther. 2020 May;33(3):e13380. doi: 10.1111/dth.13380. Epub 2020 Apr 16.
7
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): An Interplay among Drugs, Viruses, and Immune System.药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）：药物、病毒与免疫系统之间的相互作用
Int J Mol Sci. 2017 Jun 9;18(6):1243. doi: 10.3390/ijms18061243.
8
The DRESS syndrome: a literature review.药物反应伴嗜酸性粒细胞增多和全身性症状（DRESS）综合征：文献综述。
Am J Med. 2011 Jul;124(7):588-97. doi: 10.1016/j.amjmed.2011.01.017. Epub 2011 May 17.