Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Dermatol Ther. 2020 May;33(3):e13380. doi: 10.1111/dth.13380. Epub 2020 Apr 16.
A severe cutaneous drug reaction resembling acute generalized exanthematous pustulosis resulting from ingestion of hydroxychloroquine has been documented. It is distinguishable by its longer incubation period, more varied morphology with initially urticarial and later targetoid and arcuate plaques, recalcitrance to therapy and longer duration. Given the anticipated surge in the use of hydroxychloroquine due to its reported benefits in those with coronavirus disease 2019, specific recognition of this entity is pivotal. We delineate it as generalized pustular figurate erythema.
已记录到羟氯喹引起的类似于急性全身性发疹性脓疱病的严重皮肤药物反应。其潜伏期较长，形态更为多样，最初为荨麻疹样，随后为靶形和弓形斑块，对治疗有抗性且持续时间较长，因此可以与之区分。鉴于羟氯喹因其在 2019 年冠状病毒病患者中的获益而预期使用量会增加，因此对这种疾病的明确认识至关重要。我们将其描述为全身性脓疱性图形红斑。
