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低钾性瘫痪揭示原发性干燥综合征:病例报告。

Hypokalemic Paralysis Revealing Primary Sjogren's Syndrome: A Case Report.

机构信息

Maharajgunj Medical Campus, Maharajgunj, Kathmandu, Nepal.

Manosamajik Apanga Bandi Hospital, Nakkhu, Lalitpur, Nepal.

出版信息

JNMA J Nepal Med Assoc. 2023 Sep 1;61(265):735-737. doi: 10.31729/jnma.8266.

Abstract

UNLABELLED

Sjogren's syndrome is a rare chronic autoimmune disease characterised by dry eyes and dry mouth due to autoimmune destruction of the lacrimal and salivary glands, which can occur concurrently with other autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, or thyroiditis. It can lead to renal complications such as interstitial nephritis and glomerulonephritis, with distal/ type 1 renal tubular acidosis which may result in life-threatening electrolyte imbalance. We present a case of a 35-year-old female who presented with complaints of multiple episodes of muscle weakness. Type 1 renal tubular acidosis was discovered to be the cause of her symptoms which lead to the subsequent diagnosis of Sjogren's syndrome. This is rare presentation of Sjogren's syndrome, and it poses a challenge to diagnosis. Early detection and diagnosis of Sjogren's syndrome might be difficult due to existing diagnostic criteria, which contributes to a higher likelihood of missed diagnosis.

KEYWORDS

case reports; hypokalemia; renal tubular acidosis; Sjogren's syndrome.

摘要

目的

干燥综合征是一种罕见的慢性自身免疫性疾病,其特征是由于自身免疫破坏泪腺和唾液腺而导致眼睛和口腔干燥,可与类风湿关节炎、系统性红斑狼疮或甲状腺炎等其他自身免疫性疾病同时发生。它可导致间质性肾炎和肾小球肾炎等肾脏并发症,伴有远端/1 型肾小管性酸中毒,可能导致危及生命的电解质失衡。我们报告了一例 35 岁女性,其主要表现为反复发作的肌肉无力。发现 1 型肾小管性酸中毒是其症状的原因,进而诊断为干燥综合征。这是干燥综合征的罕见表现,诊断具有挑战性。由于现有的诊断标准,干燥综合征的早期检测和诊断可能较为困难,这导致漏诊的可能性更高。

关键词

病例报告;低钾血症;肾小管性酸中毒;干燥综合征。

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