Bachmann E, Weber E, Zbinden G
Cancer Treat Rep. 1987 Apr;71(4):361-6.
In animal models anthracyclines and anthracenediones show similar antineoplastic activity but somewhat different cardiotoxicity. The effects of doxorubicin and the free base of mitoxantrone (NSC-279836) on the energy metabolism of the rat heart were compared. Both compounds not only reduced oxygen consumption in heart mitochondria ex vivo, but also uncoupled oxidative phosphorylation, inhibited creatine phosphate kinase, and damaged the semipermeability of the inner mitochondrial membrane (measured as creatine influx). The effects on the myocyte membrane activities, calcium transport, and Na/K, Mg, and Ca ATPases were slightly different for the two compounds. Cardiotoxicity of the two compounds may have its origin in their interference with heart cell energy metabolism.
在动物模型中，蒽环类药物和蒽二酮类药物显示出相似的抗肿瘤活性，但心脏毒性略有不同。比较了阿霉素和米托蒽醌游离碱（NSC - 279836）对大鼠心脏能量代谢的影响。两种化合物不仅在体外降低了心脏线粒体的氧消耗，还使氧化磷酸化解偶联，抑制了肌酸磷酸激酶，并破坏了线粒体内膜的半透性（以肌酸内流来衡量）。两种化合物对心肌细胞膜活性、钙转运以及钠/钾、镁和钙ATP酶的影响略有不同。这两种化合物的心脏毒性可能源于它们对心脏细胞能量代谢的干扰。
