Baran Jakub, Borys Damian, Brzeziński Karol, Gajewski Jan, Silarski Michał, Chug Neha, Coussat Aurélien, Czerwiński Eryk, Dadgar Meysam, Dulski Kamil, Eliyan Kavya V, Gajos Aleksander, Kacprzak Krzysztof, Kapłon Łukasz, Klimaszewski Konrad, Konieczka Paweł, Kopeć Renata, Korcyl Grzegorz, Kozik Tomasz, Krzemień Wojciech, Kumar Deepak, Lomax Antony J, McNamara Keegan, Niedźwiecki Szymon, Olko Paweł, Panek Dominik, Parzych Szymon, Perez Del Rio Elena, Raczyński Lech, Simbarashe Moyo, Sharma Sushil, Shopa Roman Y, Skóra Tomasz, Skurzok Magdalena, Stasica Paulina, Stępień Ewa Ł, Tayefi Keyvan, Tayefi Faranak, Weber Damien C, Winterhalter Carla, Wiślicki Wojciech, Moskal Paweł, Ruciński Antoni
Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, 11 Łojasiewicza St 30-348 Kraków, Poland; Total-Body Jagiellonian-PET Laboratory, Jagiellonian University, 30-348 Kraków, Poland; Center for Theranostics, Jagiellonian University, Kraków, Poland.
Silesian University of Technology, Department of Systems Biology and Engineering, Gliwice, Poland; Biotechnology Centre, Silesian University of Technology, Gliwice, Poland; Institute of Nuclear Physics Polish Academy of Sciences, 31-342, Kraków, Poland.
Phys Med. 2024 Feb;118:103301. doi: 10.1016/j.ejmp.2024.103301. Epub 2024 Jan 29.
The aim of this work is to investigate the feasibility of the Jagiellonian Positron Emission Tomography (J-PET) scanner for intra-treatment proton beam range monitoring.
The Monte Carlo simulation studies with GATE and PET image reconstruction with CASToR were performed in order to compare six J-PET scanner geometries. We simulated proton irradiation of a PMMA phantom with a Single Pencil Beam (SPB) and Spread-Out Bragg Peak (SOBP) of various ranges. The sensitivity and precision of each scanner were calculated, and considering the setup's cost-effectiveness, we indicated potentially optimal geometries for the J-PET scanner prototype dedicated to the proton beam range assessment.
The investigations indicate that the double-layer cylindrical and triple-layer double-head configurations are the most promising for clinical application. We found that the scanner sensitivity is of the order of 10 coincidences per primary proton, while the precision of the range assessment for both SPB and SOBP irradiation plans was found below 1 mm. Among the scanners with the same number of detector modules, the best results are found for the triple-layer dual-head geometry. The results indicate that the double-layer cylindrical and triple-layer double-head configurations are the most promising for the clinical application, CONCLUSIONS:: We performed simulation studies demonstrating that the feasibility of the J-PET detector for PET-based proton beam therapy range monitoring is possible with reasonable sensitivity and precision enabling its pre-clinical tests in the clinical proton therapy environment. Considering the sensitivity, precision and cost-effectiveness, the double-layer cylindrical and triple-layer dual-head J-PET geometry configurations seem promising for future clinical application.
本研究旨在探讨雅盖隆正电子发射断层扫描仪（J-PET）用于治疗中质子束射程监测的可行性。
使用GATE进行蒙特卡罗模拟研究，并使用CASToR进行PET图像重建，以比较六种J-PET扫描仪的几何结构。我们用单束铅笔束（SPB）和不同射程的扩展布拉格峰（SOBP）模拟了聚甲基丙烯酸甲酯体模的质子照射。计算了每个扫描仪的灵敏度和精度，并考虑到设置的成本效益，指出了用于质子束射程评估的J-PET扫描仪原型的潜在最佳几何结构。
研究表明，双层圆柱形和三层双头配置在临床应用中最具前景。我们发现，扫描仪的灵敏度约为每一个初级质子10次符合事件，而对于SPB和SOBP照射计划，射程评估的精度均低于1毫米。在具有相同数量探测器模块的扫描仪中，三层双头几何结构的结果最佳。结果表明，双层圆柱形和三层双头配置在临床应用中最具前景。结论：我们进行的模拟研究表明，J-PET探测器用于基于PET的质子束治疗射程监测具有可行性，其灵敏度和精度合理，能够在临床质子治疗环境中进行临床前测试。考虑到灵敏度、精度和成本效益，双层圆柱形和三层双头J-PET几何结构配置在未来临床应用中似乎很有前景。
