超声引导下竖脊肌平面阻滞对腹腔镜经腹腹膜前修补术后疼痛的影响:一项前瞻性、双盲、随机对照研究
Effect of Ultrasound-Guided Erector Spinae Plane Block on Pain After Laparoscopic Transabdominal Preperitoneal Repair: A Prospective, Double-Blind, Randomized Controlled Study.
作者信息
Duan Lei, Wang Zepeng, Sun Mengliang, Huang Ligang, Ye Qing, Wang Haiquan
出版信息
Altern Ther Health Med. 2024 Sep;30(9):366-374.
OBJECTIVE
The present study was performed to evaluate the effect of ultrasound-guided erector spinae plane block (ESPB) on pain after laparoscopic transabdominal preperitoneal (TAPP) repair. Therefore, improved postoperative pain management is crucial for enhancing the overall patient experience and recovery.
METHODS
This prospective, double-blind, randomized controlled trial enrolled 40 male patients with a unilateral inguinal hernia at Xi'an Aerospace General Hospital from November 1, 2020, to February 1, 2021. Participants were assigned through a random number table at a 1:1 ratio to receive either ESPB with 20 ml 0.5% ropivacaine in the experimental group (Group E) or ESPB with 20 ml normal saline in the control group (Group C), with 20 cases in each group. The primary outcome was assessed using visual analogue scale (VAS) scores for exercise pain at 2h, 6h, 12h, 18h, and 24h postoperatively. Secondary outcomes included time lapses before patient-controlled intravenous analgesia (PCIA) use, intraoperative remifentanil usage, additional sufentanil, postoperative nalbuphine consumption, analgesic remedies at 24h postoperatively, and incidence of postoperative adverse events.
RESULTS
Group E provided more pain mitigation for patients than Group C, as evidenced by the significantly lower VAS scores during exercise pain at 2h (Group C: 1.95±1.19; Group E:4.00±1.38), 6h (Group C: 2.00±1.12; Group E:3.90±1.37), and 12h (Group C: 2.05±1.05; Group E:3.55±1.36) postoperatively (P < .05), and the pain mitigation for Group C was significant only at 18h and 24h postoperatively compared to at 2h postoperatively (P < .05). Group E resulted in significantly reduced intraoperative use of remifentanil and, additional sufentanil and postoperative nalbuphine consumption versus Group C (P < .05). Group E exhibited a better pain tolerance than Group C, as demonstrated by the longer time lapse before the use of PCIA (RR value=5.709, t=8.446, P < .05). Group C required more analgesic remedies within 24 h after surgery than Group E (P < .05). Group E did not increase the risk of postoperative adverse events, given the absence of statistical significance in the intergroup comparison (P > .05).
CONCLUSION
Ultrasound-guided ESPB demonstrates notable benefits by decreasing intraoperative and postoperative anesthetic drug requirements, enhancing pain management, and elevating postoperative comfort and quality of life for patients. While acknowledging the study's limitations, it is crucial to highlight the potential clinical implications of these findings. The incorporation of ESPB with ropivacaine into postoperative pain management protocols could represent a significant advancement in clinical practice. The observed improvements in pain management and reduced reliance on anesthetic drugs may lead to more tailored and efficient postoperative care, potentially enhancing patient recovery experiences. Further research and practical implementation studies are warranted to fully elucidate the specific impact and optimal integration of ESPB with ropivacaine within broader clinical settings.
目的
本研究旨在评估超声引导下竖脊肌平面阻滞(ESPB)对腹腔镜经腹腹膜前修补术(TAPP)后疼痛的影响。因此,改善术后疼痛管理对于提升患者的整体体验和恢复至关重要。
方法
本前瞻性、双盲、随机对照试验纳入了2020年11月1日至2021年2月1日在西安航天总医院就诊的40例单侧腹股沟疝男性患者。通过随机数字表以1:1的比例将参与者分为两组,实验组(E组)接受20ml 0.5%罗哌卡因的ESPB,对照组(C组)接受20ml生理盐水的ESPB,每组20例。主要结局指标采用术后2小时、6小时、12小时、18小时和24小时运动疼痛的视觉模拟量表(VAS)评分进行评估。次要结局指标包括患者自控静脉镇痛(PCIA)使用前的时间间隔、术中瑞芬太尼使用量、额外舒芬太尼使用量、术后纳布啡消耗量、术后24小时的镇痛补救措施以及术后不良事件的发生率。
结果
与C组相比,E组为患者提供了更多的疼痛缓解,术后2小时(C组:1.95±1.19;E组:4.00±1.38)、6小时(C组:2.00±1.12;E组:3.90±1.37)和12小时(C组:2.05±1.05;E组:3.55±1.36)运动疼痛时的VAS评分显著更低(P < 0.05),与术后2小时相比,C组仅在术后18小时和24小时疼痛缓解显著(P < 0.05)。与C组相比,E组术中瑞芬太尼、额外舒芬太尼的使用量以及术后纳布啡消耗量显著减少(P < 0.05)。E组比C组表现出更好的疼痛耐受性,PCIA使用前的时间间隔更长(RR值 = 5.709,t = 8.446,P < 0.05)。C组术后24小时内所需的镇痛补救措施比E组更多(P < 0.05)。鉴于组间比较无统计学意义(P > 0.05),E组并未增加术后不良事件的风险。
结论
超声引导下的ESPB通过降低术中及术后麻醉药物需求、加强疼痛管理以及提高患者术后舒适度和生活质量显示出显著益处。尽管认识到本研究的局限性,但强调这些发现的潜在临床意义至关重要。将罗哌卡因的ESPB纳入术后疼痛管理方案可能代表临床实践中的一项重大进展。观察到的疼痛管理改善和对麻醉药物依赖的减少可能导致更具针对性和高效的术后护理,潜在地提升患者的恢复体验。有必要进行进一步的研究和实际应用研究,以充分阐明ESPB与罗哌卡因在更广泛临床环境中的具体影响和最佳整合方式。