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超声引导技术用于腹腔镜袖状胃切除术患者的术后镇痛:竖脊肌平面阻滞与腰方肌阻滞的比较

Ultrasound-Guided Techniques for Postoperative Analgesia in Patients Undergoing Laparoscopic Sleeve Gastrectomy: Erector Spinae Plane Block vs. Quadratus Lumborum Block.

作者信息

Ashoor Tarek M, Jalal Ahmed S, Said Alfred Maurice, Ali Mohamed M, Esmat Ibrahim M

机构信息

Department of Anesthesia, Intensive Care, and Pain Management, Ain-Shams University, Cairo, Egypt.

Department of Anesthesia and Intensive Care, The National Institute of Diabetes and Endocrinology, Cairo, Egypt.

出版信息

Pain Physician. 2023 May;26(3):245-256.

Abstract

BACKGROUND

Laparoscopic sleeve gastrectomy (LSG) is a common bariatric surgery. Regional anesthetic techniques decrease postoperative pain, narcotic analgesic requirements, and opioid-related adverse effects in patients scheduled for bariatric surgery.

OBJECTIVES

The research team conducted this clinical trial to assess the effects of bilateral ultrasound (US)-guided erector spinae plane block (ESPB) on postoperative pain scores and postoperative analgesics consumption compared with bilateral US-guided quadratus lumborum block (QLB) in the first 24 hours following LSG.

STUDY DESIGN

A randomized, double-blind, prospective, single-center study.

SETTING

Ain-Shams University Hospitals.

METHODS

Patients: One hundred twenty morbidly obese patients were scheduled for LSG.

INTERVENTION

Were randomly assigned to 3 groups (40 each): bilateral US-guided ESPB, bilateral US-guided QLB, or control (C) group.

MEASUREMENTS

The time to first rescue analgesia (ketorolac) was considered as a primary outcome. The time to perform the block, the duration of anesthesia, the time to first ambulation, the visual analog scale (VAS) at rest, VAS at movement, the total nalbuphine consumption (mg), the total requirements of rescue analgesia (ketorolac) over the first 24 hours after surgery and the study safety profile were considered as secondary outcomes.

RESULTS

The time to perform the block and the duration of anesthesia were higher in the QLB group compared to other groups, with significant differences between ESPB and C groups (P < 0.001, P < 0.001, respectively). The ESPB and QLB groups were superior to the C group as regards the time to first rescue analgesia, the total dose of rescue analgesia, and the total nalbuphine consumption (P < 0.001, P < 0.001, P < 0.001, respectively). In the C group, VAS-R and VAS-M readings were higher in the first 18 hours after surgery (P < 0.001, P < 0.001, respectively). In the rest 6 hours of 24 hours after surgery, the QLB group had lower VAS-R and VAS-M readings than the C group (P < 0.001, P < 0.001, respectively). More patients in the C group had higher incidences of nausea and vomiting (P = 0.011, P = 0.002, respectively). In the C group, the time to first ambulation, the length of PACU stay, and the hospital stay were higher in comparison to the ESPB and QLB groups (P < 0.001, P < 0.001, P < 0.001, respectively). More patients in the ESPB and QLB groups were satisfied with postoperative pain management protocol (P < 0.001).

LIMITATIONS

The lack of postoperative respiratory assessment (e.g., spirometry) precluded the identification of either ESPB or QLB effects on pulmonary functions in such patients.

CONCLUSION

Bilateral ultrasound-guided erector spinae plane block and bilateral ultrasound-guided quadratus lumborum block provided adequate postoperative pain control and reduced postoperative analgesic requirements for morbidly obese patients scheduled for laparoscopic sleeve gastrectomy with priority to bilateral erector spinae plane block.

摘要

背景

腹腔镜袖状胃切除术(LSG)是一种常见的减肥手术。区域麻醉技术可减轻接受减肥手术患者的术后疼痛、减少麻醉性镇痛药需求及与阿片类药物相关的不良反应。

目的

研究团队开展此项临床试验,以评估在LSG术后的头24小时内,与双侧超声引导下腰方肌阻滞(QLB)相比,双侧超声引导下竖脊肌平面阻滞(ESPB)对术后疼痛评分及术后镇痛药消耗量的影响。

研究设计

一项随机、双盲、前瞻性、单中心研究。

地点

艾因夏姆斯大学医院。

方法

患者:120例病态肥胖患者计划接受LSG手术。

干预措施

随机分为3组(每组40例):双侧超声引导下ESPB组、双侧超声引导下QLB组或对照组(C组)。

测量指标

首次使用补救镇痛药(酮咯酸)的时间被视为主要结局指标。实施阻滞的时间、麻醉持续时间、首次下床活动时间、静息视觉模拟评分(VAS)、活动时VAS、纳布啡总消耗量(mg)、术后头24小时内补救镇痛药(酮咯酸)的总需求量以及研究的安全性指标被视为次要结局指标。

结果

与其他组相比,QLB组实施阻滞的时间和麻醉持续时间更长,ESPB组与C组之间存在显著差异(分别为P<0.001,P<0.001)。在首次使用补救镇痛药的时间、补救镇痛药的总剂量和纳布啡总消耗量方面,ESPB组和QLB组均优于C组(分别为P<0.001,P<0.001,P<0.001)。在C组中,术后头18小时内静息VAS和活动时VAS读数更高(分别为P<0.001,P<0.001)。在术后24小时的其余6小时内,QLB组的静息VAS和活动时VAS读数低于C组(分别为P<0.001,P<0.001)。C组中更多患者恶心和呕吐的发生率更高(分别为P = 0.011,P = 0.002)。与ESPB组和QLB组相比,C组首次下床活动时间、麻醉后恢复室(PACU)停留时间和住院时间更长(分别为P<0.001,P<0.001,P<0.001)。ESPB组和QLB组中更多患者对术后疼痛管理方案感到满意(P<0.001)。

局限性

缺乏术后呼吸评估(如肺活量测定),无法确定ESPB或QLB对此类患者肺功能的影响。

结论

双侧超声引导下竖脊肌平面阻滞和双侧超声引导下腰方肌阻滞可为计划接受腹腔镜袖状胃切除术的病态肥胖患者提供充分的术后疼痛控制,并减少术后镇痛药需求,双侧竖脊肌平面阻滞更具优势。

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