Pesticide Residue Laboratory, AINP on Pesticide Residues, Anand Agricultural University, Anand, 388110, Gujarat, India.
Environ Sci Pollut Res Int. 2024 Feb;31(10):15186-15198. doi: 10.1007/s11356-024-32135-1. Epub 2024 Jan 30.
Combination product of two herbicides, i.e. iprovalicarb and copper oxychloride, is a new formulation. There is paucity of data on the dissipation pattern and risk assessment of this combination product in crops. To understand the dissipation behaviour/kinetics of this product, a supervised field trial was undertaken on cucumber and tomato. Method validation for a QuEChERS-based method for analysis of these pesticides from cucumber and tomato matrices reveals that all the parameters were within the acceptance range in accordance with SANTE. The limit of quantitation (LOQ) for iprovalicarb in cucumber and tomato fruits, and in soil matrices when analysed on LC-MS/MS was established at 0.01 mg kg. Similarly, the LOQ for copper oxychloride (as copper) on ICP-MS was established at 0.5 mg kg in cucumber and tomato fruits and 5.0 mg kg in soil. Dissipation of iprovalicarb was slower in tomato fruits as compared to cucumber fruits. The initial accumulation of the residues of iprovalicarb was 0.073 and 0.243 mg kg in cucumber and 0.214 and 0.432 mg kg in tomato fruits at standard and double dose, respectively. Similarly, copper oxychloride residues were 3.51 and 6.45 mg kg in cucumber and 1.26 and 2.56 mg kg in tomato fruits at standard and double dose, respectively. The residues were below LOQ in cucumber fruits, tomato fruits and soil at the time of harvest. The residues of copper oxychloride persisted till harvest time in cucumber fruits and in soil. A preharvest interval (PHI) of 3 day is recommended on safer side for the combination product of iprovalicarb + copper oxychloride. Theoretical maximum daily intake (TMDI) is less than maximum permissible intake (MPI) for iprovalicarb and copper oxychloride at both the doses from 0 day and onward. The results from the present study can be of immense importance for establishing label claims, maximum residue limits (MRLs) and risk assessment by national and international regulatory agencies.
两种除草剂异丙威和氧氯化铜的组合产品是一种新制剂。关于该组合产品在作物中的消解模式和风险评估，数据很少。为了了解该产品的消解行为/动力学特性，在黄瓜和番茄上进行了一项有监督的田间试验。基于 QuEChERS 的方法用于分析黄瓜和番茄基质中的这些农药，方法验证表明，所有参数均符合 SANTE 的要求，在可接受范围内。LC-MS/MS 分析时，在黄瓜和番茄果实以及土壤基质中，异丙威的定量限 (LOQ) 定为 0.01 mg/kg。同样，ICP-MS 分析时，铜氧氯化物（以铜计）在黄瓜和番茄果实中的 LOQ 定为 0.5 mg/kg，在土壤中的 LOQ 定为 5.0 mg/kg。与番茄果实相比，异丙威在番茄果实中的消解速度较慢。在标准和双倍剂量下，异丙威在黄瓜中的初始残留量分别为 0.073 和 0.243 mg/kg，在番茄中的初始残留量分别为 0.214 和 0.432 mg/kg。同样，铜氧氯化物在黄瓜中的残留量分别为 3.51 和 6.45 mg/kg，在番茄中的残留量分别为 1.26 和 2.56 mg/kg。收获时，黄瓜和番茄果实以及土壤中的残留量均低于 LOQ。在黄瓜果实和土壤中，铜氧氯化物的残留量一直持续到收获期。为安全起见，推荐异丙威+铜氧氯化物组合产品的采收前间隔 (PHI) 为 3 天。从 0 天开始，对于两种剂量的异丙威和铜氧氯化物，理论最大日摄入量 (TMDI) 均低于最大允许摄入量 (MPI)。本研究的结果对于国家和国际监管机构制定标签声明、最大残留限量 (MRL) 和风险评估具有重要意义。
