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家族性地中海热背景下的胃、结肠和直肠淀粉样变性：难治性腹泻的独特病因。

Gastric, Colonic, and Rectal Amyloidosis in the Setting of Familial Mediterranean Fever: A Unique Cause of Intractable Diarrhea.

作者信息

Bathobakae Lefika, Ansari Nida, Mahmoud Anas, Hasan Shayee, Yuridullah Ruhin, Qayyum Sohail, Rae Sam

机构信息

Internal Medicine, St. Joseph's University Medical Center, Paterson, USA.

Gastroenterology and Hepatology, St. Joseph's University Medical Center, Paterson, USA.

出版信息

Case Rep Gastrointest Med. 2024 Jan 23;2024:6679725. doi: 10.1155/2024/6679725. eCollection 2024.

DOI:10.1155/2024/6679725
PMID:38292345
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10827378/
Abstract

Familial Mediterranean fever (FMF) is a hereditary disorder characterized by episodes of fever, polyserositis, or cutaneous inflammation. The FMF attacks last 1-3 days and have no apparent triggers. Recurrent deposition of the serum amyloid A (SAA) protein in the gut can cause intractable diarrhea, dysmotility, and recurrent abdominal pain. Gastrointestinal amyloidosis is a rare, but serious, complication of FMF. In this case report, we describe a rare case of chronic diarrhea and recurrent abdominal pain due to FMF-induced gastrointestinal amyloidosis.

摘要

家族性地中海热（FMF）是一种遗传性疾病，其特征为发热、多浆膜炎或皮肤炎症发作。FMF发作持续1 - 3天，且无明显诱因。血清淀粉样蛋白A（SAA）在肠道反复沉积可导致顽固性腹泻、动力障碍和反复腹痛。胃肠道淀粉样变性是FMF一种罕见但严重的并发症。在本病例报告中，我们描述了一例因FMF引起的胃肠道淀粉样变性导致慢性腹泻和反复腹痛的罕见病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/831b/10827378/ddb593e5561f/CRIGM2024-6679725.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/831b/10827378/f37e745746b1/CRIGM2024-6679725.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/831b/10827378/ddb593e5561f/CRIGM2024-6679725.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/831b/10827378/f37e745746b1/CRIGM2024-6679725.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/831b/10827378/ddb593e5561f/CRIGM2024-6679725.002.jpg

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Secondary Amyloidosis Presenting as Ischemic Proctitis.表现为缺血性直肠炎的继发性淀粉样变性
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Atypical Familial Mediterranean Fever Complicated with Gastrointestinal Amyloidosis Diagnosed due to Paroxysmal Arthralgia and Intractable Diarrhea, Successfully Treated with Tocilizumab.非典型家族性地中海热合并胃肠道淀粉样变性，因阵发性关节痛和顽固性腹泻而确诊，用托珠单抗成功治疗。
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Successful treatment with humanized anti-interleukin-6 receptor antibody (tocilizumab) in a case of AA amyloidosis complicated by familial Mediterranean fever.人源化抗白细胞介素-6受体抗体（托珠单抗）成功治疗一例合并家族性地中海热的AA型淀粉样变性病例。
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