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抗炎治疗成功治愈充血性缺血性结肠炎:一例报告

Congestive ischemic colitis successfully treated with anti-inflammatory therapy: A case report.

作者信息

Lee Geon Woo, Park Su Bum

机构信息

Department of Internal Medicine, Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, South Korea.

出版信息

World J Clin Cases. 2024 Jan 6;12(1):142-147. doi: 10.12998/wjcc.v12.i1.142.

Abstract

BACKGROUND

Congestive ischemic colitis is a rare subtype of ischemic colitis with an unknown pathophysiology. Excluding conservative management, such as fasting, no established treatment exists; therefore, surgical intervention should be considered in some cases if symptoms worsen. Current literature suggests that anti-inflammatory agents may effectively treat congestive ischemic colitis.

CASE SUMMARY

We present the case of a 68-year-old female patient who underwent laparoscopic left hemicolectomy for transverse colon cancer 3 years ago. Postoperatively, follow-up included an annual colonoscopy and abdominal computed tomography (CT) at a local clinic. However, progressive erythema and edema of the sigmoid colon were observed 1 year postoperatively. Upon admission to our hospital, she complained of abdominal pain and diarrhea. Abdominal CT showed thickening of the sigmoid colon walls, and colonoscopy revealed erythema, edema, and multiple ulcers with exudate in the sigmoid colon. CT angiography showed engorgement of the sigmoid vasa recta without any vascular abnormalities. The diagnosis was congestive ischemic colitis, and we treated the patient with anti-inflammatory agents. After 2 mo of glucocorticoid therapy (20 mg once daily) and 7 mo of 5-aminosalicylate therapy (1 g twice daily), the ulcers completely healed. She has not experienced any recurrence for 2 years.

CONCLUSION

Anti-inflammatory therapy, specifically glucocorticoids and 5-aminosalicylate, has demonstrated promising efficacy and introduces potential novel treatment options for congestive ischemic colitis.

摘要

背景

充血性缺血性结肠炎是缺血性结肠炎的一种罕见亚型,其病理生理学尚不清楚。除禁食等保守治疗外,尚无既定的治疗方法;因此,如果症状恶化,在某些情况下应考虑手术干预。目前的文献表明,抗炎药可能有效治疗充血性缺血性结肠炎。

病例摘要

我们报告一例68岁女性患者,她3年前因横结肠癌接受了腹腔镜左半结肠切除术。术后,在当地诊所进行的随访包括每年一次的结肠镜检查和腹部计算机断层扫描(CT)。然而,术后1年观察到乙状结肠出现进行性红斑和水肿。入院时,她主诉腹痛和腹泻。腹部CT显示乙状结肠壁增厚,结肠镜检查显示乙状结肠有红斑、水肿和多处伴有渗出物的溃疡。CT血管造影显示乙状结肠直血管充血,无任何血管异常。诊断为充血性缺血性结肠炎,我们用抗炎药对患者进行了治疗。经过2个月的糖皮质激素治疗(每日一次,每次20mg)和7个月的5-氨基水杨酸治疗(每日两次,每次1g),溃疡完全愈合。她2年来未出现任何复发。

结论

抗炎治疗,特别是糖皮质激素和5-氨基水杨酸,已显示出有前景的疗效,并为充血性缺血性结肠炎引入了潜在的新治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/945d/10824190/7fad7bdef737/WJCC-12-142-g001.jpg

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