Liu Xu-Rui, Wen Ze-Lin, Liu Fei, Li Zi-Wei, Liu Xiao-Yu, Zhang Wei, Peng Dong
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Department of Gastrointestinal Surgery, Yongchuan Hospital of Chongqing Medical University, Chongqing 402160, China.
World J Gastrointest Oncol. 2024 Jan 15;16(1):133-143. doi: 10.4251/wjgo.v16.i1.133.
Gastric cancer (GC) and colorectal cancer (CRC) are the fifth and third most common cancer worldwide, respectively. Nowadays, GC is reported to have a potential predictive value for CRC, especially for advanced CRC.
To evaluate the necessity of colonoscopy for gastric neoplasm (GN) patients.
Four databases, including PubMed, EMBASE, the Cochrane Library, and Ovid, were used to perform the search strategy on May 2, 2023. The prevalence of colorectal neoplasms (CRN) and baseline characteristics were compared between the neoplasm group and the control group. Continuous variables are expressed as the mean difference and standard deviation. Relationships of categorical variables in the two groups are expressed as odds ratios (OR) and 95% confidence intervals (95%CIs). Subgroup analysis according to different kinds of GNs was conducted for more in-depth analysis. The results of this study are represented by forest plots. Publication bias was evaluated by a funnel plot. All data analyses were performed by STATA SE 16.0 software.
A total of 3018 patients with GNs and 3905 healthy controls (age and sex matched) were enrolled for analysis. After comparing the prevalence of CRNs between the two groups, CRNs were detected significantly more frequently in GN patients than in controls (OR = 1.69, 95%CI = 1.28 to 2.23, = 85.12%, = 0.00), especially in patients with GC (OR =1.80, 95%CI = 1.49 to 2.18, = 25.55%, < 0.1). Moreover, other risk factors including age (OR = 1.08, 95%CI = 1.00 to 1.17, = 90.13%, = 0.00) and male sex (OR = 2.31, 95%CI = 1.26 to 4.22, = 87.35%, = 0.00), were related to the prevalence of CRNs. For patients in the GN group, body mass index (BMI, OR = 0.88, 95%CI = 0.80 to 0.98, = 0.00%, = 0.92) and smoking (OR = 1.03, 95%CI = 1.01 to 1.05, = 0.00%, = 0.57) were protective and risk factors for CRNs, respectively.
Patients are recommended to undergo colonoscopy when diagnosed with GNs, especially GC patients with a low BMI and a history of smoking.
胃癌（GC）和结直肠癌（CRC）分别是全球第五和第三大常见癌症。如今，据报道GC对CRC具有潜在的预测价值，尤其是对晚期CRC。
评估胃癌（GN）患者进行结肠镜检查的必要性。
2023年5月2日，使用包括PubMed、EMBASE、Cochrane图书馆和Ovid在内的四个数据库执行检索策略。比较肿瘤组和对照组中结直肠肿瘤（CRN）的患病率及基线特征。连续变量以平均差和标准差表示。两组分类变量之间的关系以比值比（OR）和95%置信区间（95%CIs）表示。根据不同类型的GN进行亚组分析以进行更深入的分析。本研究结果以森林图表示。通过漏斗图评估发表偏倚。所有数据分析均使用STATA SE 16.0软件进行。
共纳入3018例GN患者和3905例年龄和性别匹配的健康对照进行分析。比较两组CRN的患病率后发现，GN患者中CRN的检出频率显著高于对照组（OR = 1.69，95%CI = 1.28至2.23，I² = 85.12%，P = 0.00），尤其是GC患者（OR = 1.80，95%CI = 1.49至2.18，I² = 25.55%，P < 0.1）。此外，其他危险因素包括年龄（OR = 1.08，95%CI = 1.00至1.17，I² = 90.13%，P = 0.00）和男性（OR = 2.31，95%CI = 1.26至4.22，I² = 87.35%，P = 0.00），均与CRN的患病率相关。对于GN组患者，体重指数（BMI，OR = 0.88，95%CI = 0.80至0.98，I² = 0.00%，P = 0.92）和吸烟（OR = 1.03，95%CI = 1.01至1.05，I² = 0.00%，P = 0.57）分别是CRN的保护因素和危险因素。
建议诊断为GN的患者进行结肠镜检查，尤其是BMI低且有吸烟史的GC患者。
