布美他尼对毛细血管通透性肺水肿的作用。

Effect of bumetanide in capillary permeability pulmonary oedema.

作者信息

Ali J, Duke K

出版信息

Can J Anaesth. 1987 Jan;34(1):9-13. doi: 10.1007/BF03007674.

DOI:10.1007/BF03007674

PMID:3829293

Abstract

UNLABELLED

To determine if bumetanide, like furosemide, improves shunt through pulmonary vasoactivity, 20 dogs with unilobar oleic acid pulmonary oedema were studied. Fractional perfusion and intrapulmonary shunt of the oedematous lobe were measured at: baseline, 1 1/2 hours after oleic acid infusion, 15 minutes later after either 0.1 mg X kg-1 of bumetanide in ten dogs (Bumetanide Group) or without bumetanide in ten dogs (Control Group), and 2 1/2 hours after the oleic acid, the bumetanide being administered immediately after the 1 1/2 hours post-oleic acid measurements. Lobar shunts for the Bumetanide Group were: 9.3 +/- 4.0, 54.3 +/- 13.6, 54.7 +/- 13.6, 38.6 +/- 12.0 per cent and for

CONTROLS

8.7 +/- 1.6, 45.1 +/- 8.8, 48.3 +/- 7.8, 70.4 +/- 6.2 per cent. Fractional perfusions of the oedematous lobe were: 29.9 +/- 1, 14.7 +/- 1.1, 14.6 +/- 0.7, 19.3 +/- 1.9 per cent in the Bumetanide Group and 28.6 +/- 2.1, 14.2 +/- 1.1, 14.2 +/- 1.5, and 9.9 +/- 1.1 per cent in CONTROLS. Oedema (wet to body weight ratio) was less (p less than 0.05) in the contralateral lobe (2.5 +/- 0.2 vs. 2.9 +/- 0.3) and the oedematous lobe (4.7 +/- 0.4 vs 6.0 +/- 0.5) after bumetanide-induced diuresis. We conclude that bumetanide decreases shunt by decreasing oedema and not through pulmonary vasoactivity.

摘要

未标记

为了确定布美他尼是否像呋塞米一样，通过肺血管活性改善分流，对20只患有单叶油酸肺水肿的犬进行了研究。在以下时间点测量水肿叶的灌注分数和肺内分流：基线、油酸输注后1.5小时、10只犬静脉注射0.1mg/kg布美他尼（布美他尼组）或10只犬不注射布美他尼（对照组）15分钟后、油酸注射后2.5小时，布美他尼在油酸注射后1.5小时测量后立即给药。布美他尼组的叶分流分别为：9.3±4.0%、54.3±13.6%、54.7±13.6%、38.6±12.0%，对照组为：8.7±1.6%、45.1±8.8%、48.3±7.8%、70.4±6.2%。水肿叶的灌注分数在布美他尼组为：29.9±1%、14.7±1.1%、14.6±0.7%、19.3±1.9%，对照组为：28.6±2.1%、14.2±1.1%、14.2±1.5%、9.9±1.1%。布美他尼诱导利尿后，对侧叶（2.5±0.2对2.9±0.3）和水肿叶（4.7±0.4对6.0±0.5）的水肿（湿重比）较小（p<0.05）。我们得出结论，布美他尼通过减轻水肿而非通过肺血管活性来减少分流。