Fujita Y, Wakabayashi K, Takayama S, Nagao M, Sugimura T
Carcinogenesis. 1987 Apr;8(4):527-9. doi: 10.1093/carcin/8.4.527.
A mutagenic nitrosation product of tyramine, 4-(2-aminoethyl)-6-diazo-2,4-cyclohexadienone (3-diazotyramine, 3-DT) preferentially induced tumors of the oral cavity. Squamous-cell carcinomas of the mucosa of the oral cavity floor developed in 19 out of 28 male F344 rats administered 0.1% 3-DT in their drinking water. Tyramine and nitrite are found at fairly high concentrations in various foods. This demonstration of the carcinogenicity of 3-DT indicates that although the implications of 3-DT for human cancer are not clear, other nitrosable mutagen precursors need to be tested as possible risk factors in human cancer.
酪胺的一种诱变亚硝化产物，4-(2-氨基乙基)-6-重氮-2,4-环己二烯酮（3-重氮酪胺，3-DT）优先诱发口腔肿瘤。在28只饮用含0.1% 3-DT饮用水的雄性F344大鼠中，有19只发生了口腔底部黏膜鳞状细胞癌。在各种食物中发现酪胺和亚硝酸盐的浓度相当高。3-DT致癌性的这一证明表明，尽管3-DT对人类癌症的影响尚不清楚，但其他可亚硝化的诱变前体作为人类癌症可能的风险因素需要进行测试。
