Karhuvaara Outi, Vilén Liisa, Nuutila Jari, Putus Tuula, Atosuo Janne
The Laboratory of Immunochemistry, Department of Biotechnology, Faculty of Science and Engineering, University of Turku, Turku, Finland.
Environmental Medicine and Occupational Health, Department of Clinical Medicine, Faculty of Medicine, University of Turku, Turku, Finland.
Heliyon. 2024 Jan 8;10(2):e24104. doi: 10.1016/j.heliyon.2024.e24104. eCollection 2024 Jan 30.
Indoor exposure to microbial growth, caused by moisture damage, has been an established health risk for several decades. It is likely that a damp indoor environment contains biological pollutants that trigger both the innate and adaptive branches of the immune system. In this study, we investigated the association between moisture damage related microbial exposure and serum C3a, C5a and CRP concentrations in Finnish adults. Serum C3a and CRP concentrations were elevated in individuals exposed to moisture damage and microbial growth in an indoor air environment. The elevated concentrations may be due to environmental factors present in moisture-damaged buildings. Complement activation and the resulting proinflammatory cleavage products may be a driving factor in inflammatory responses following exposure to indoor moisture damage and related microbial growth.
几十年来，因受潮损坏导致的室内微生物生长暴露一直是公认的健康风险。潮湿的室内环境很可能含有引发免疫系统先天性和适应性分支的生物污染物。在本研究中，我们调查了芬兰成年人中与受潮损坏相关的微生物暴露与血清C3a、C5a和CRP浓度之间的关联。在室内空气环境中暴露于受潮损坏和微生物生长的个体中，血清C3a和CRP浓度升高。浓度升高可能是由于受潮损坏建筑物中存在的环境因素。补体激活及由此产生的促炎裂解产物可能是暴露于室内受潮损坏及相关微生物生长后炎症反应的驱动因素。
