中年糖尿病患者的生理认知衰退综合征：握力与血糖控制及认知评分显著相关。
Physio-cognitive decline syndrome among middle-aged diabetes patients: Handgrip strength significantly correlates with glycaemic control and cognitive score.
作者信息
Laksmi Purwita Wijaya, Purnamasari Dyah, Sofian Naldo, Sari Nina Kemala, Kurniawan Mohammad, Sukrisman Lugyanti, Tahapary Dicky Levenus, Dwimartutie Noto, Rinaldi Ikhwan
机构信息
Geriatric Division, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Endocrinology, Metabolism, and Diabetes Division, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
出版信息
Heliyon. 2024 Jan 5;10(2):e24018. doi: 10.1016/j.heliyon.2024.e24018. eCollection 2024 Jan 30.
AIMS
To investigate the correlation between glycaemic control with component of Physio-Cognitive Decline Syndrome (PCDS) and among each component of PCDS itself.
METHODS
A cross sectional study was conducted (January 2021-November 2022) at Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia on consecutively recruited T2DM outpatients aged 40-59 years old. Data on the latest three months HbA1c, hand grip strength (HGS), usual gait speed (GS), and Indonesian Montreal Cognitive Assessment (MoCA-Ina) were evaluated. Pearson or Spearman's test was used to analyse the correlations.
RESULTS
There were 133 subjects with median age 53 (40-59) years. The PCDS was found in 48.1 % subjects, of which 64.1 % with uncontrolled glycaemia. Significant correlations were found between HGS and HbA1c (r = -0.24, R = 0.06, < 0.01) and MoCA-Ina score (r = 0.21, R = 0.04, p < 0.05).
CONCLUSION
The higher HbA1c and the lower MoCA-Ina score, the weaker handgrip strength was.
目的
研究血糖控制与生理认知功能衰退综合征（PCDS）各组成部分之间以及PCDS各组成部分自身之间的相关性。
方法
于2021年1月至2022年11月在印度尼西亚雅加达的Cipto Mangunkusumo医院进行了一项横断面研究，连续招募40 - 59岁的2型糖尿病门诊患者。评估了最近三个月的糖化血红蛋白（HbA1c）、握力（HGS）、日常步态速度（GS）和印度尼西亚蒙特利尔认知评估（MoCA-Ina）的数据。采用Pearson或Spearman检验分析相关性。
结果
共有133名受试者，中位年龄为53（40 - 59）岁。48.1%的受试者存在PCDS，其中64.1%的患者血糖控制不佳。发现握力与HbA1c之间存在显著相关性（r = -0.24，R = 0.06，< 0.01）以及与MoCA-Ina评分之间存在显著相关性（r = 0.21，R = 0.04，p < 0.05）。
结论
糖化血红蛋白水平越高，MoCA-Ina评分越低，握力越弱。
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