Centers for Disease Control and Prevention, Division of Vector-Borne Diseases, Fort Collins, Colorado, USA.
Missouri Department of Health and Senior Services, Jefferson City, Missouri, USA.
Clin Infect Dis. 2024 Jan 31;78(Suppl 1):S67-S70. doi: 10.1093/cid/ciad688.
Tularemia is caused by the highly infectious bacterium Francisella tularensis, which is recognized as a Tier 1 bioterrorism agent. Tularemia has a range of recognized clinical manifestations, but fewer than 20 bone or joint infections from 6 countries have been reported in the literature to date. This series includes 13 cases of F. tularensis septic arthritis or osteomyelitis in the United States during 2004-2023 and describes exposures, clinical presentation, diagnosis, and outcomes for this rare but severe form of tularemia. Clinicians should consider F. tularensis in patients with compatible exposures or a history of joint replacement or immunosuppression.
兔热病由高度传染性的弗朗西斯菌引起，被认为是一级生物恐怖主义制剂。兔热病有一系列公认的临床表现，但迄今为止，文献中仅报道了来自 6 个国家的不到 20 例骨骼或关节感染。本系列包括 2004 年至 2023 年期间美国的 13 例弗朗西斯菌败血性关节炎或骨髓炎病例，并描述了这种罕见但严重的兔热病的暴露、临床表现、诊断和结果。对于有相关接触史或关节置换或免疫抑制病史的患者，临床医生应考虑弗朗西斯菌。
