通过定量免疫电泳研究人α-间胰蛋白酶抑制剂及免疫相关抑制剂。II. 病理状况。

Human inter-alpha-trypsin inhibitor and immunologically related inhibitors investigated by quantitative immunoelectrophoresis. II. Pathological conditions.

作者信息

Odum L, Hansen-Nord G, Byrjalsen I

出版信息

Clin Chim Acta. 1987 Jan 30;162(2):189-98. doi: 10.1016/0009-8981(87)90450-5.

Abstract

Inter-alpha-trypsin inhibitor (I alpha I) and the immunologically related prealbumin-like-migrating proteinase inhibitor (pA-PI) were investigated by crossed immunoelectrophoresis in sera from 68 persons with myocardial infarction, neoplastic diseases, inflammatory diseases, collagenosis, cirrhosis of the liver or uremia. The concentration of pA-PI in serum increased during each of these diseases (p less than 0.01). The concentration of I alpha I was significantly decreased in patients with cirrhosis (p less than 0.01). In day to day studies of a patient with myocardial infarction, a patient with erysipelas and a postoperative patient the concentration of I alpha I was low normal to decreased in the first days of the conditions and increased thereafter to high normal values. A comparison of the concentration of pA-PI with the excretion of the immunologically identical urinary proteinase inhibitor (UPI) showed that the excretion could not be caused by simple overflow of pA-PI in the kidney. The excretion of UPI followed closely the acute-phase-response, as measured by serum C-reactive protein.

摘要

采用交叉免疫电泳法对68例患有心肌梗死、肿瘤性疾病、炎症性疾病、胶原病、肝硬化或尿毒症的患者血清中的α-胰蛋白酶抑制剂（IαI）和免疫相关的前白蛋白样迁移蛋白酶抑制剂（pA-PI）进行了研究。在上述每种疾病期间，血清中pA-PI的浓度均升高（p<0.01）。肝硬化患者血清中IαI的浓度显著降低（p<0.01）。在对一名心肌梗死患者、一名丹毒患者和一名术后患者进行的日常研究中，IαI的浓度在病情初期处于低正常水平至降低状态，此后升高至高正常水平。将pA-PI的浓度与免疫相同的尿蛋白酶抑制剂（UPI）的排泄量进行比较，结果表明，UPI的排泄并非由肾脏中pA-PI的简单溢出所致。UPI的排泄与血清C反应蛋白所测定的急性期反应密切相关。