Computational Biomechanics Research Laboratory, Mechanical and Industrial Engineering Department, University of Illinois at Chicago, Chicago, IL, USA.
Proc Inst Mech Eng H. 2024 Feb;238(2):149-159. doi: 10.1177/09544119231217240. Epub 2024 Jan 31.
The sclera exhibits mechanical response when subjected to an external electric stimulation. The scleral electroactive response is a function of its charge density, mechanical properties, thickness, and strength of the applied electric voltage. The primary objective of the present work was to investigate the regional differences in the electroactive response of porcine sclera. To this end, we cut scleral strips in meridional directions from superior-temporal, superior-nasal, inferior-temporal, and inferior-nasal quadrants. In addition, we excised samples circumferentially from the posterior, equatorial, and anterior regions. The electroactive bending response of these samples was measured under 10 and 15 V in 0.15 M NaCl solution. The meridional samples were tested under two different configurations by clamping them either from their anterior or posterior end. It was observed that the scleral electroactive deformation increased with increasing the the electric voltage. Furthermore, regardless of the region from which meridional strips were excised, their electroactive response was considerably larger when they were clamped from their anterior end. Unlike meridional strips, the electroactive response of circumferential samples was significantly dependent on the location, that is, the average maximum bending angle of posterior samples was significantly larger than that of equatorial and anterior strips. The regionally different electroactive bending response of the sclera was discussed in terms of the variation in its biochemical and biomechanical properties throughout the eyeball.
巩膜在受到外部电刺激时会表现出机械响应。巩膜的电致活性响应是其电荷密度、力学性能、厚度和施加的电电压强度的函数。本工作的主要目的是研究猪巩膜电活性响应的区域差异。为此，我们沿子午方向从颞上、鼻上、颞下和鼻下象限切割巩膜条。此外，我们还从后极、赤道和前极周围切取样本。在 0.15 M NaCl 溶液中，在 10 和 15 V 下测量这些样品的电致弯曲响应。子午样品通过从前部或后部夹住它们进行两种不同的配置进行测试。结果表明，巩膜的电致变形随着外加电压的增加而增加。此外，无论从哪个区域切取子午带，从前部夹住它们时，其电致活性响应都明显更大。与子午带不同，环向样本的电致活性响应明显取决于位置，即后向样本的平均最大弯曲角度明显大于赤道和前向样本。根据眼球内生物化学和生物力学性质的变化，讨论了巩膜区域不同的电致弯曲响应。
