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[成人免疫球蛋白A血管炎]

[Adult IgA vasculitis].

作者信息

Hankard Antoine, Audemard-Verger Alexandra

机构信息

Service de médecine interne, CHU de Caen, Caen, France.

Service de médecine interne, CHU de Tours, Tours, France.

出版信息

Rev Prat. 2023 Dec;73(10):1124-1130.

Abstract

ADULT IGA VASCULITIS. IgA vasculitis previously named rheumatoid purpura is a rare systemic vasculitis in adults involving small vessels and associated with the presence of immunoglobulin A deposits. IgA vasculitis is often triggerd by infections, taking medication and vaccination. It is characterised by the presence of vascular purpura associated with joint (arthralgia), gastrointestinal (abdominal pain) and sometimes renal involvement (glomerulonephritis). Gastrointestinal involvement can be lifethreatening (bowel perforation), while the longterm prognosis is shaped by the renal involvement (renal failure). In most cases, the disease has a good outcome and only symptomatic treatment is recommended. In more severe forms, corticosteroids, combined with another immunosuppressant or biotherapy, may be discussed on a casebycase basis.

摘要

成人IgA血管炎。IgA血管炎以前称为类风湿性紫癜,是一种罕见的成人系统性血管炎,累及小血管,并与免疫球蛋白A沉积有关。IgA血管炎通常由感染、用药和接种疫苗引发。其特征是出现与关节(关节痛)、胃肠道(腹痛)相关的血管性紫癜,有时还伴有肾脏受累(肾小球肾炎)。胃肠道受累可能危及生命(肠穿孔),而长期预后则由肾脏受累(肾衰竭)决定。在大多数情况下,该病预后良好,仅建议进行对症治疗。对于更严重的形式,可根据具体情况讨论使用皮质类固醇联合另一种免疫抑制剂或生物疗法。

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