Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Capital Medical University, No.1 Dong Jiao Min Xiang, Beijing, 100730, China.
Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany.
Graefes Arch Clin Exp Ophthalmol. 2024 Jun;262(6):1919-1924. doi: 10.1007/s00417-023-06355-z. Epub 2024 Jan 31.
Dysthyroid optic neuropathy (DON) leads to vision loss. This study aimed to investigate a new method that can directly evaluate the change in muscle cone inner volume (MCIV) and distinguish DON orbits from non-DONs.
This study included 54 patients (108 orbits) who were diagnosed with thyroid eye disease and treated at the Beijing Tongren Hospital between December 2019 and September 2021. The extraocular muscle volume (EOMV), orbital fat volume (OFV), and bony orbit volume (BOV) of the patients were measured using three-dimensional reconstruction. MCIV was measured using artificially defined boundaries. The associations between these volumes and clinical indicators were studied, and the diagnostic efficacy of these volumes for DON was described using receiver operating characteristic (ROC) curves.
The ROC curve showed that the area under the curve of MCIV/BOV (%) combined with EOMV/BOV (%) reached 0.862 (p < 0.001), with a sensitivity of 85.7% and a specificity of 76.1%.
The combination of MCIV/BOV (%) and EOMV/BOV (%) is a good indicator for the diagnosis of DON, which aids in the early detection and intervention of DON.
甲状腺相关眼病性视神经病变（DON）可导致视力丧失。本研究旨在探索一种可直接评估内直肌圆锥内体积（MCIV）变化并区分 DON 眼眶与非 DON 眼眶的新方法。
本研究纳入了 2019 年 12 月至 2021 年 9 月在北京同仁医院就诊的甲状腺眼病患者 54 例（108 只眼眶）。采用三维重建测量患者的眼外肌体积（EOMV）、眶脂体积（OFV）和骨性眼眶体积（BOV）。使用人工定义的边界测量 MCIV。研究了这些体积与临床指标之间的关系，并使用受试者工作特征（ROC）曲线描述了这些体积对 DON 的诊断效能。
ROC 曲线显示，MCIV/BOV（%）与 EOMV/BOV（%）的曲线下面积达到 0.862（p<0.001），敏感度为 85.7%，特异度为 76.1%。
MCIV/BOV（%）与 EOMV/BOV（%）的联合是 DON 诊断的良好指标，有助于早期发现和干预 DON。
