在辅助生殖技术周期中，自我报告的种族背景与整倍体状态和活产率的相关性。

Correlation of self-reported racial background to euploidy status and live birth rates in assisted reproductive technology cycles.

机构信息

Reproductive Medicine Associates of New York, New York, NY, USA.

Obstetrics, Gynecology and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

出版信息

J Assist Reprod Genet. 2024 Mar;41(3):693-702. doi: 10.1007/s10815-024-03039-3. Epub 2024 Jan 31.

DOI:10.1007/s10815-024-03039-3

PMID:38294622

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10957844/

Abstract

PURPOSE

To determine whether the embryonic euploidy rate and live birth outcomes following single, euploid embryo transfer (SEET) differ among women of self-reported racial and ethnic backgrounds.

METHODS

This retrospective cohort study included all infertile patients of different self-reported racial backgrounds who underwent In vitro fertilization (IVF) with preimplantation genetic testing for aneuploidy (PGT-A) and an autologous single euploid embryo transfer (SEET) from December 2015 to December 2019 at a single private and academic assisted reproduction technology center. Primary outcome measures included ploidy rates among different racial groups. Secondary outcomes included clinical pregnancy, clinical pregnancy loss, and live birth rates.

RESULTS

Five thousand five hundred sixty-two patients who underwent an IVF cycle with ICSI-PGT-A were included. A total of 24,491 blastocysts were analyzed. White participants had on average more euploid embryos and higher euploidy rates when compared to their counterparts (p ≤ 0.0001). However, after controlling for confounding factors, there was no association between race and the odds of having a higher euploidy rate (aOR 1.31; 95% CI 0.63-2.17, p = 0.42). A total of 4949 patients underwent SEET. Pregnancy outcomes did not differ among patients of varying self-reported races.

CONCLUSIONS

Euploidy rates and pregnancy outcomes were comparable among patients of different racial backgrounds who underwent a SEET.

摘要

目的

确定在接受单胚胎移植（SEET）的患者中，自我报告的种族和民族背景是否会影响胚胎的整倍体率和活产结局。

方法

本回顾性队列研究纳入了 2015 年 12 月至 2019 年 12 月在一家私立和学术辅助生殖技术中心接受体外受精（IVF）和胚胎植入前遗传学检测（PGT-A）以及自体单整倍体胚胎移植（SEET）的不同自我报告的种族背景的所有不孕患者。主要结局指标包括不同种族群体的整倍体率。次要结局包括临床妊娠、临床妊娠丢失和活产率。

结果

共纳入 5562 例接受 IVF 周期联合卵胞浆内单精子注射（ICSI）-PGT-A 的患者。共分析了 24491 个囊胚。与对照组相比，白人患者平均有更多的整倍体胚胎和更高的整倍体率（p≤0.0001）。然而，在控制混杂因素后，种族与更高整倍体率的几率之间没有关联（优势比 1.31；95%置信区间 0.63-2.17，p=0.42）。共有 4949 例患者接受 SEET。不同自我报告种族的患者的妊娠结局无差异。