Nagy J, Miltényi M, Dobos M, Burger T
Clin Nephrol. 1987 Feb;27(2):76-8.
In the renal biopsy samples of some patients with IgA glomerulonephritis (IgA GN), tubulointerstitial changes and a significant correlation between these changes and the serum creatinine levels had been observed earlier. In order to get an insight into the function of the tubules, 45 patients with IgA GN have been examined for proteinuria with special reference to low molecular weight (LMW) proteins, also called tubular proteins using sodium-dodecylsulphate polyacrylamide gel electrophoresis (SDS-PAGE). Thirty-seven of the 45 patients had proteinuria (200-1890 mg/day). On the basis of the middle molecular weight/high molecular weight (MMW/HMW) protein ratio, the proteinuria was non-selective in 28. Twenty-nine patients had 40-200 mg LMW protein/day in the urine. There was a statistically significant correlation between the tubulointerstitial changes seen in the renal biopsy samples (characterized by the tubulointerstitial index) and the tubular proteinuria. On the basis of these results it is suggested that in most patients with IgA GN there is, in addition to the glomerular lesion, also morphological and functional tubulointerstitial damage, which is in connection with the progression of the disease.
在一些IgA肾小球肾炎（IgA GN）患者的肾活检样本中，早期已观察到肾小管间质改变以及这些改变与血清肌酐水平之间的显著相关性。为了深入了解肾小管的功能，对45例IgA GN患者进行了蛋白尿检查，特别关注低分子量（LMW）蛋白，即使用十二烷基硫酸钠聚丙烯酰胺凝胶电泳（SDS-PAGE）的肾小管蛋白。45例患者中有37例出现蛋白尿（200 - 1890毫克/天）。根据中分子量/高分子量（MMW/HMW）蛋白比率，28例患者的蛋白尿为非选择性。29例患者尿液中LMW蛋白含量为40 - 200毫克/天。肾活检样本中所见的肾小管间质改变（以肾小管间质指数为特征）与肾小管性蛋白尿之间存在统计学显著相关性。基于这些结果，提示在大多数IgA GN患者中，除了肾小球病变外，还存在形态学和功能性肾小管间质损伤，这与疾病的进展有关。
