Department of Medicine II, Hematology/Oncology, Goethe University, University Hospital, Frankfurt, Germany.
Hospital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.
Blood. 2024 May 9;143(19):1891-1902. doi: 10.1182/blood.2023020794.
Working groups of the European LeukemiaNet have published several important consensus guidelines. Acute lymphoblastic leukemia (ALL) has many different clinical and biological subgroups and the knowledge on disease biology and therapeutic options is increasing exponentially. The European Working Group for Adult ALL has therefore summarized the current state of the art and provided comprehensive consensus recommendations for diagnostic approaches, biologic and clinical characterization, prognostic factors, and risk stratification as well as definitions of endpoints and outcomes. Aspects of treatment, management of subgroups and specific situations, aftercare, and supportive care are covered in a separate publication. The present recommendation intends to provide guidance for the initial management of adult patients with ALL and to define principles as a basis for future collaborative research.
欧洲白血病网的工作组已经发布了几项重要的共识指南。急性淋巴细胞白血病（ALL）有许多不同的临床和生物学亚组，并且对疾病生物学和治疗选择的认识正在呈指数级增长。因此，欧洲成人 ALL 工作组总结了目前的最新进展，并提供了全面的共识建议，包括诊断方法、生物学和临床特征、预后因素和风险分层以及终点和结果的定义。治疗方面、亚组和特定情况的管理、后续护理和支持性护理在另一篇单独的出版物中进行了介绍。本建议旨在为成人 ALL 患者的初始治疗提供指导，并为未来的合作研究确定原则基础。
