Department of Gastroenterology and Hepatology, Japanese Red Cross Osaka Hospital, Japan.
Intern Med. 2024 Sep 1;63(17):2427-2432. doi: 10.2169/internalmedicine.2965-23. Epub 2024 Feb 1.
Reports of pancreatic neuroendocrine neoplasm (P-NEN) concomitant with intraductal papillary mucinous neoplasm (IPMN) are gradually increasing. However, many of these cases were diagnosed in the resected specimen incidentally. We herein report a case of minimal P-NEN concomitant with branch-duct IPMN that was successfully diagnosed preoperatively by contrast-enhanced endoscopic ultrasonography (EUS) and an EUS-guided fine-needle biopsy. These findings suggest that P-NEN as well as pancreatic ductal adenocarcinoma should be considered as concurrent tumors developing in patients with IPMNs. EUS is an essential modality when evaluating IPMN for detecting small lesions concomitant with IPMN.
胰腺神经内分泌肿瘤（P-NEN）合并胰管内乳头状黏液性肿瘤（IPMN）的报告逐渐增多。然而，这些病例中有许多是在切除标本中偶然诊断出来的。本文报告了一例分支胰管型 IPMN 合并微小 P-NEN 的病例，术前通过增强内镜超声（EUS）和 EUS 引导下细针活检成功诊断。这些发现表明，P-NEN 以及胰腺导管腺癌应被视为 IPMN 患者中并发的肿瘤。EUS 是评估 IPMN 时检测与 IPMN 并存的小病变的重要手段。
