State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Engineering Research Center of Oral Translational Medicine, Ministry of Education & National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Oral Dis. 2024 Sep;30(6):3658-3670. doi: 10.1111/odi.14874. Epub 2024 Jan 31.
The purpose of the study was to systematically evaluate the efficacy of autologous platelet concentrate products in the preservation of the alveolar ridge after tooth extraction through meta-analysis and provide a theoretical basis for the clinical application of autologous platelet concentrates to reduce alveolar bone resorption.
This study conducted a meta-analysis of clinical trials between 2013 and 2023, focusing on autologous platelet concentrate products (e.g., PRP, PRF, CGF, and PRCF) used for alveolar ridge preservation after tooth extraction. The analysis included 122 articles and 371 extraction sockets. All statistical analyses were performed using Review Manager version 5.4.
Results indicate that these platelet concentrates effectively reduced changes in horizontal width 1 mm below the alveolar crest and vertical socket height. They also promoted a higher percentage of new bone formation in extraction sockets compared with control groups. However, they did not significantly prevent horizontal bone resorption at 3 and 5 mm below the alveolar crest.
In conclusion, autologous platelet concentrates are useful for alveolar ridge preservation, but larger clinical studies are needed to confirm these findings due to the relatively small sample size in this study.
本研究通过荟萃分析系统评估了自体血小板浓缩物产品在拔牙后牙槽嵴保存中的疗效，为临床应用自体血小板浓缩物减少牙槽骨吸收提供理论依据。
本研究对 2013 年至 2023 年间的临床试验进行了荟萃分析，重点关注用于拔牙后牙槽嵴保存的自体血小板浓缩物产品（如 PRP、PRF、CGF 和 PRCF）。分析共纳入 122 篇文章和 371 个拔牙窝。所有统计分析均使用 Review Manager 版本 5.4 进行。
结果表明，这些血小板浓缩物可有效减少牙槽嵴下 1mm 处的水平宽度变化和牙槽窝的垂直高度。与对照组相比，它们还能促进拔牙窝中更高比例的新骨形成。然而，它们并不能显著防止牙槽嵴下 3mm 和 5mm 处的水平骨吸收。
总之，自体血小板浓缩物有助于牙槽嵴保存，但由于本研究样本量较小，需要进行更大规模的临床研究来证实这些发现。
