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[多学科团队“体外膜肺氧合团队”对难治性心源性休克和心脏骤停患者接受静脉-动脉体外膜肺氧合治疗预后的影响]

[Impact of a multidisciplinary team "ECMO Team" on the prognosis of patients undergoing veno-arterial extracorporeal membrane oxygenation for refractory cardiogenic shock and cardiac arrest].

作者信息

Seoane Leonardo A, Burgos Lucrecia, Vila Rocío Baro, Furmento Juan F, Costabel Juan P, Vrancic Mariano, Villagra Maximiliano, Ramírez-Hoyos Olga D, Navia Daniel, Diez Mirta

机构信息

Servicio de Cardiología Crítica, Departamento de Cardiología, ICBA Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina. Servicio de Cardiología Crítica Departamento de Cardiología ICBA Instituto Cardiovascular de Buenos Aires Buenos Aires Argentina.

Sección de Insuficiencia Cardíaca, Departamento de Cardiología, ICBA Instituto Cardiovascular, Buenos Aires, Argentina. Sección de Insuficiencia Cardíaca Departamento de Cardiología ICBA Instituto Cardiovascular Buenos Aires Argentina.

出版信息

Arch Peru Cardiol Cir Cardiovasc. 2023 Dec 27;4(4):132-140. doi: 10.47487/apcyccv.v4i4.325. eCollection 2023 Oct-Dec.

Abstract

OBJECTIVES

Veno-arterial Extracorporeal membrane oxygenation (VA ECMO) is a salvage intervention in patients with cardiogenic shock (CS), and cardiac arrest (CA) refractory to standard therapies. The design of ECMO Teams has achieved the standardization of processes, although its impact on survival and prognosis is unknown.

OBJECTIVE

We aimed to analyze whether the creation of an ECMO Team has modified the prognosis of patients undergoing VA ECMO for refractory CS or CA.

MATERIALS AND METHODS

. We conducted a single-center retrospective cohort study. Patients with refractory CS or CA who underwent VA ECMO were divided in two consecutive periods: from 2014 to April 2019 (pre-ECMO T) and from May 2019 to December 2022 (Post ECMO T). The main outcomes were survival on ECMO, in-hospital survival, complications, and annual ECMO volume.

RESULTS

Eighty-three patients were included (36 pre-ECMO T and 47 post-ECMO T). The mean age was 53 +/-13 years. The most common reason for device indication was different: postcardiotomy shock (47.2%) pre-ECMO T and refractory cardiogenic shock (29.7%) post-ECMO T. The rate of extracorporeal cardiopulmonary resuscitation was 14.5%. The median duration of VA ECMO was longer after ECMO team implementation: 8 days (IQR 5-12.5) vs. five days (IQR 2-9, p=0.04). Global in-hospital survival was 45.8% (38.9% pre-ECMO T vs. 51.1% post-ECMO T; p=0.37), and the survival rate from VA ECMO was 60.2% (55.6% pre-ECMO T vs 63.8% post-ECMO T; p= 0.50). The volume of VA ECMO implantation was significantly higher in the post-ECMO team period (13.2 +/3.5 per year vs. 6.5 +/-3.5 per year, p: 0.02). The rate of complications was similar in both groups.

CONCLUSIONS

After the implementation of an ECMO team, there was no statistical difference in the survival rate of patients treated with VA ECMO. However, a significant increase in the number of patients supported per year was observed after the implementation of this multidisciplinary team. Post-ECMO T, the most common reason for device indication was cardiogenic shock, with longer run times and a higher rate of extracorporeal cardiopulmonary resuscitation.

摘要

目的

静脉-动脉体外膜肺氧合(VA ECMO)是对心源性休克(CS)和标准治疗难治性心脏骤停(CA)患者的一种挽救性干预措施。ECMO团队的组建已实现了流程标准化,但其对生存率和预后的影响尚不清楚。

目的

我们旨在分析ECMO团队的组建是否改变了因难治性CS或CA接受VA ECMO治疗患者的预后。

材料与方法

我们进行了一项单中心回顾性队列研究。将因难治性CS或CA接受VA ECMO治疗的患者分为两个连续时间段:2014年至2019年4月(ECMO团队组建前)和2019年5月至2022年12月(ECMO团队组建后)。主要结局指标为ECMO期间生存率、院内生存率、并发症及每年的ECMO使用量。

结果

共纳入83例患者(ECMO团队组建前36例,ECMO团队组建后47例)。平均年龄为53±13岁。设备使用指征的最常见原因有所不同:ECMO团队组建前为心脏术后休克(47.2%),ECMO团队组建后为难治性心源性休克(29.7%)。体外心肺复苏率为14.5%。ECMO团队组建后VA ECMO的中位持续时间更长:8天(四分位间距5 - 12.5天) vs. 5天(四分位间距2 - 9天,p = 0.04)。总体院内生存率为45.8%(ECMO团队组建前38.9% vs. ECMO团队组建后51.1%;p = 0.37),VA ECMO的生存率为60.2%(ECMO团队组建前55.6% vs. ECMO团队组建后63.8%;p = 0.50)。ECMO团队组建后VA ECMO植入量显著更高(每年13.2±3.5例 vs. 每年6.5±3.5例,p = 0.02)。两组并发症发生率相似。

结论

ECMO团队组建后,接受VA ECMO治疗患者的生存率无统计学差异。然而,该多学科团队组建后,每年接受支持治疗的患者数量显著增加。ECMO团队组建后,设备使用指征的最常见原因是心源性休克,运行时间更长,体外心肺复苏率更高。

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