miR-143-3p 水平低与严重的慢性鼻-鼻窦炎伴鼻息肉有关。
Low levels of miR-143-3p are associated with severe chronic rhinosinusitis with nasal polyps.
机构信息
INGENIO, Clinical and Experimental Respiratory Immunoallergy (IRCE), Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain; Universitat de Barcelona. Barcelona, Catalonia, Spain.
INGENIO, Clinical and Experimental Respiratory Immunoallergy (IRCE), Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain; CIBER of Respiratory Diseases (CIBERES), Carlos III Health Institute, Madrid, Spain;Rhinology Unit and Smell Clinic, ENT Department, Hospital Clinic Barcelona, Universitat de Barcelona, Barcelona, Catalonia, Spain.
出版信息
Rhinology. 2024 Aug 1;62(4):506-508. doi: 10.4193/Rhin23.332.
microRNAs (miRNAs) are small, single-stranded, non-coding RNA molecules that regulate post-transcriptional gene expression. Accumulating evidence suggests their involvement in regulating various biological and pathological processes, including inflammation. Studies have revealed distinct expression patterns of miRNAs in Chronic Rhinosinusitis with (CRSwNP) and without (CRSsNP) nasal polyps (1). Specifically, miR-155 and miR-21 have been observed to be upregulated in CRSwNP, increasing and attenuating the expression of pro-inflammatory cytokines, respectively (2,3). Conversely, the downregulation of miR-34, miR-449, and members of the miR-200 family has been associated with impaired ciliogenesis and the regulation of epithelial-mesenchymal transition, respectively (4,5). Nonetheless, the direct role of miRNAs in CRSwNP is still being investigated.
microRNAs (miRNAs) 是小的、单链的、非编码 RNA 分子，可调节转录后基因表达。越来越多的证据表明它们参与调节各种生物和病理过程，包括炎症。研究表明，miRNAs 在伴有鼻息肉的慢性鼻-鼻窦炎（CRSwNP）和不伴鼻息肉的慢性鼻-鼻窦炎（CRSsNP）中的表达模式不同（1）。具体而言，已经观察到 miR-155 和 miR-21 在 CRSwNP 中上调，分别增加和减弱促炎细胞因子的表达（2,3）。相反，miR-34、miR-449 和 miR-200 家族成员的下调与纤毛生成受损和上皮-间充质转化的调节有关（4,5）。然而，miRNAs 在 CRSwNP 中的直接作用仍在研究中。
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