Mental Health Center, West China Hospital of Sichuan University, No. 28 Dian Xin Nan Jie, Wuhou District, Chengdu, China.
Radiology Department, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital. C.T.), No. 20, Xi Mian Qiao Heng Jie, Wuhou District, Chengdu, China.
Cereb Cortex. 2024 Jan 31;34(2). doi: 10.1093/cercor/bhad523.
Methamphetamine is a highly addictive psychostimulant drug that is abused globally and is a serious threat to health worldwide. Unfortunately, the specific mechanism underlying addiction remains unclear. Thus, this study aimed to investigate the characteristics of functional connectivity in the brain network and the factors influencing methamphetamine use disorder in patients using magnetic resonance imaging. We included 96 abstinent male participants with methamphetamine use disorder and 46 age- and sex-matched healthy controls for magnetic resonance imaging. Compared with healthy controls, participants with methamphetamine use disorder had greater impulsivity, fewer small-world attributes of the resting-state network, more nodal topological attributes in the cerebellum, greater functional connectivity strength within the cerebellum and between the cerebellum and brain, and decreased frontoparietal functional connectivity strength. In addition, after controlling for covariates, the partial correlation analysis showed that small-world properties were significantly associated with methamphetamine use frequency, psychological craving, and impulsivity. Furthermore, we revealed that the small-word attribute significantly mediated the effect of methamphetamine use frequency on motor impulsivity in the methamphetamine use disorder group. These findings may further improve our understanding of the neural mechanism of impulse control dysfunction underlying methamphetamine addiction and assist in exploring the neuropathological mechanism underlying methamphetamine use disorder-related dysfunction and rehabilitation.
甲基苯丙胺是一种高度成瘾的精神兴奋剂药物，在全球范围内被滥用，对全球健康构成严重威胁。不幸的是，成瘾的具体机制仍不清楚。因此，本研究旨在使用磁共振成像技术研究脑网络功能连接的特征以及影响甲基苯丙胺使用障碍患者的因素。我们纳入了 96 名男性甲基苯丙胺使用障碍的戒断参与者和 46 名年龄和性别匹配的健康对照者进行磁共振成像。与健康对照组相比，甲基苯丙胺使用障碍患者的冲动性更高，静息态网络的小世界属性更少，小脑的节点拓扑属性更多，小脑和大脑之间的功能连接强度更大，额顶叶功能连接强度降低。此外，在控制协变量后，部分相关分析表明，小世界特性与甲基苯丙胺使用频率、心理渴求、冲动性显著相关。此外，我们还揭示了小世界属性显著介导了甲基苯丙胺使用频率对甲基苯丙胺使用障碍组运动冲动的影响。这些发现可能进一步提高我们对甲基苯丙胺成瘾导致冲动控制功能障碍的神经机制的理解，并有助于探索与甲基苯丙胺使用障碍相关功能障碍和康复相关的神经病理学机制。
