Takano K, Ogiuchi H, Hizuka N, Sangu Y, Shizume K
Endocrinol Jpn. 1986 Oct;33(5):655-64. doi: 10.1507/endocrj1954.33.655.
Detailed oro-maxillofacial studies using dental cast, pantomogram and cephalogram were performed in 43 patients with GH deficiency aged 7-17 years and compared statistically to the results from 62 short children with normal GH secretion. The dental age was retarded as compared to the chronological age in patients with GH deficiency by a mean of 2.0 +/- 1.3 years. This value did not differ statistically from that observed in normal short children (1.7 +/- 0.8 years). However the bone age was significantly retarded in patients with GH deficiency (3.2 +/- 1.7 yrs vs 1.5 +/- 1.1 yrs, p less than 0.001). There was no difference between tooth size or cephalogram analysis results in the children in the two groups. The coronal arch length, basal arch width and basal arch length were shorter in patients with GH deficiency. These data indicate underdevelopment of the maxilla in patients with GH deficiency.
对43例7至17岁生长激素缺乏症患者进行了详细的口腔颌面研究，使用牙模、全景X线片和头颅侧位片，并与62例生长激素分泌正常的矮小儿童的结果进行统计学比较。生长激素缺乏症患者的牙龄比实际年龄平均延迟2.0±1.3岁。该值与正常矮小儿童中观察到的值（1.7±0.8岁）在统计学上无差异。然而，生长激素缺乏症患者的骨龄明显延迟（3.2±1.7岁对1.5±1.1岁，p<0.001）。两组儿童的牙齿大小或头颅侧位片分析结果无差异。生长激素缺乏症患者的牙弓长度、基骨弓宽度和基骨弓长度较短。这些数据表明生长激素缺乏症患者上颌骨发育不全。
