Fuchs A G, Mariotto R, De Lustig E S
Eur J Cancer Clin Oncol. 1986 Nov;22(11):1347-52. doi: 10.1016/0277-5379(86)90143-4.
We have determined serum copper levels in BALB/c female mice subcutaneously inoculated with two related mammary adenocarcinoma tumors. Serum copper content increased progressively with tumor size in animals bearing either variant, and reached levels up to four times those of control mice. In contrast, copper levels detected by cytochemistry in tumor cells are higher in the slow growing tumor variant. It is suggested that the stronger angiogenic effect previously described for this variant could be related to its higher cellular copper content.
我们测定了皮下接种两种相关乳腺腺癌肿瘤的BALB/c雌性小鼠的血清铜水平。在携带任一变异体的动物中，血清铜含量随肿瘤大小逐渐增加，达到对照小鼠的四倍。相比之下，在生长缓慢的肿瘤变异体中，通过细胞化学检测到的肿瘤细胞中的铜水平更高。有人提出，先前描述的该变异体更强的血管生成作用可能与其更高的细胞铜含量有关。
