Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
Curr Pharm Des. 2024;30(5):333-351. doi: 10.2174/0113816128282470240117072322.
Due to its important biological and pharmacological properties, in the field of medicinal chemistry and drug discovery, the N-acylhydrazone motif has shown to be extremely adaptable and promising. This scaffold has become a crucial component in the synthesis of numerous bioactive agents. -Acylhydrazones are also interesting biological and synthetic tools due to their easy and straightforward synthesis. The current review provides a summary of the analgesic and anti-inflammatory activities of -acylhydrazone derivatives over the past ten years. A brief discussion of structure-activity relationships is also provided which may guide researchers in medicinal chemistry to develop derivatives based on -acylhydrazone scaffold as potent anti-inflammatory candidates.
由于其重要的生物学和药理学性质，在药物化学和药物发现领域，N-酰腙结构基序被证明是非常适应性强和有前途的。这个支架已经成为许多生物活性物质合成的关键组成部分。由于其易于合成，-酰腙也是有趣的生物和合成工具。本综述概述了过去十年中 -酰腙衍生物的镇痛和抗炎活性。还简要讨论了构效关系，这可能为药物化学研究人员提供指导，以开发基于 -酰腙支架的具有潜力的抗炎候选物衍生物。
