Wake Addisu Dabi
Arsi University, Asella, Ethiopia.
Glob Pediatr Health. 2024 Jan 31;11:2333794X231226071. doi: 10.1177/2333794X231226071. eCollection 2024.
. The burden of severe acute malnutrition (SAM) remains unacceptably high worldwide. The burden of Tuberculosis (TB) co-occurring with SAM in under 5 children is a significant focus for the improvement of child health. The co-existence of these diseases are significantly enhancing the associated morbidity, mortality, and hospitalization costs among this population. . To determine survival status and predictors of TB development in under 5 children with SAM in Asella Referral and Teaching Hospital, Ethiopia. . A retrospective cohort study was done in 247 under 5 children with SAM between January 01/2018 and December 31/2022. Systematic sampling technique was used to select the study participants. Data extraction format was used to collect data from the patient's medical chart. EpiData version 4.6.0.6 was used for data entry and exported to STATA version 14.2 for statistical analysis. . This study includes 247 under 5 children with SAM with a response rate of 100%. Regarding to the survival status; 24(17%) of under 5 children with SAM have developed the events (TB) and the rest of them, 205(83%) were censored. The incidence density rate (IDR) of TB in under 5 children with SAM was 45.51 per 100 (95% CI: 33.63, 61.58) children-months observation. The cumulative incidence of TB was 17% (95% CI: 12.79, 22.25). Multivariable Cox proportional hazard analysis revealed that: having a history of TB contact (AHR = 5.56, 95% CI: 2.77, 11.15, -value = .000), having a history of bottle feeding (AHR = 4.95, 95%CI: 1.08, 22.77, -value = .040), did not take F100 (AHR = 1.71, 95% CI: 1.12, 7.25, -value = .00) were statistically significant predictors of TB development. . This study shows that the IDR of TB was high. Having a history of TB contact, history of bottle feeding, and not taking F100 were significant predictors of TB development. It is vital to address these predictors to prevent the development of TB in this population. Moreover, early screening of TB in these children should get high emphasize.
全球范围内，重度急性营养不良（SAM）的负担仍然高得令人无法接受。五岁以下儿童中同时患有结核病（TB）和SAM的情况是改善儿童健康的一个重要关注点。这些疾病的共存显著增加了该人群的相关发病率、死亡率和住院费用。
为了确定埃塞俄比亚阿塞拉转诊和教学医院五岁以下患有SAM的儿童的生存状况以及结核病发展的预测因素。
对2018年1月1日至2022年12月31日期间的247名五岁以下患有SAM的儿童进行了一项回顾性队列研究。采用系统抽样技术选择研究参与者。使用数据提取格式从患者病历中收集数据。使用EpiData 4.6.0.6版本进行数据录入，并导出到STATA 14.2版本进行统计分析。
本研究纳入了247名五岁以下患有SAM的儿童，应答率为100%。关于生存状况；24名（17%）五岁以下患有SAM的儿童发生了该事件（结核病），其余205名（83%）被审查。五岁以下患有SAM的儿童中结核病的发病密度率（IDR）为每100名儿童月观察期45.51例（95%置信区间：33.63，61.58）。结核病的累积发病率为17%（95%置信区间：12.79，22.25）。多变量Cox比例风险分析显示：有结核病接触史（调整后风险比[AHR]=5.56，95%置信区间：2.77，11.15，P值=.000）、有奶瓶喂养史（AHR=4.95，95%置信区间：1.08，22.77，P值=.040）、未服用F100（AHR=1.71，95%置信区间：1.12，7.25，P值=.00）是结核病发展的统计学显著预测因素。
本研究表明，结核病的发病密度率很高。有结核病接触史、奶瓶喂养史和未服用F100是结核病发展的显著预测因素。解决这些预测因素对于预防该人群中结核病的发展至关重要。此外，应高度重视对这些儿童进行结核病的早期筛查。
