College of Life Sciences, Shandong Agricultural University, Tai'an 271018, P.R. China; Shandong Ocean Agricultural Development Co. Ltd., Jining 272600, P.R. China.
College of Life Sciences, Shandong Agricultural University, Tai'an 271018, P.R. China.
Int J Med Mushrooms. 2024;26(1):55-66. doi: 10.1615/IntJMedMushrooms.2023051288.
The liver was regarded as the most important metabolic and detoxification organ in vivo, and Morchella esculenta had been reported as the admittedly rare edible fungus belonging to Ascomycetes contributing to the abundant bioactivities. The objective of this study aimed to confirm the potential antioxidant activities of selenium mycelium polysaccharides (Se-MIP) from M. esculenta against alcoholic liver diseases (ALD) in mice. The results indicated that a selenium concentration of 25 μg/mL exhibited potential in vitro antioxidant capacities of Se-MIP. The in vivo mice results demonstrated that Se-MIP showed potential anti-ALD effects by improving the antioxidant activities and alleviating the hepatic dysfunctions. The present conclusions suggested that Se-MIP could be used as a candidate on improving ALD and its complications for further clinical investigations.
肝脏被认为是体内最重要的代谢和解毒器官，而羊肚菌被报道为一种公认的稀有食用真菌，属于子囊菌，具有丰富的生物活性。本研究旨在证实来自羊肚菌的硒菌丝体多糖（Se-MIP）对酒精性肝病（ALD）的潜在抗氧化活性。结果表明，硒浓度为 25μg/mL 时，Se-MIP 具有潜在的体外抗氧化能力。体内小鼠实验结果表明，Se-MIP 通过提高抗氧化活性和减轻肝损伤，显示出潜在的抗 ALD 作用。本结论表明，Se-MIP 可作为改善 ALD 及其并发症的候选药物，进一步进行临床研究。
