J Drugs Dermatol. 2024 Feb 1;23(2):50-53. doi: 10.36849/JDD.7928.
Moisturizers are often used as adjuvant therapy for psoriasis to assist with rehydration and skin barrier restoration. Fixed-combination halobetasol propionate 0.01% and tazarotene 0.045% lotion (HP/TAZ) is indicated for the topical treatment of plaque psoriasis in adults, with a demonstrated clinical profile in two phase 3 trials. However, the effect of application order with HP/TAZ has yet to be explored. This study evaluated the clinical profile of HP/TAZ applied before versus after a ceramide-containing moisturizer in adults with mild-to-moderate plaque psoriasis.
Sixteen participants were randomized to apply HP/TAZ followed by moisturizer on one side and moisturizer followed by HP/TAZ on the other side once daily for 12 weeks. Tolerability, safety, efficacy, and quality of life endpoints were assessed. Results: Significant Investigator's Global Assessment improvement was observed across all time points (P≤0.003) regardless of application order. Total Dermatology Life Quality Index scores significantly improved at all time points (P≤0.003), and visual analog scale for itch significantly improved at weeks 4, 8, and 12 (P<0.008). Four moderate adverse events were experienced by 3 participants. Two participants reported itching/irritation, which was worse when HP/TAZ was applied first.
The application order of moisturizer did not decrease therapeutic efficacy of HP/TAZ. Moisturizer application before HP/TAZ may reduce incidence of application site adverse events, ultimately increasing tolerability and supporting the real-world recommendation that applying a ceramide-containing moisturizer before HP/TAZ, versus after, results in a safe and effective therapeutic option for plaque psoriasis. J Drugs Dermatol. 2024;23(2):50-53. doi:10.36849/JDD.7928.
保湿剂常被用作银屑病的辅助治疗，以帮助皮肤补水和恢复皮肤屏障。固定配比卤倍他索丙酸 0.01%和他扎罗汀 0.045%乳剂（HP/TAZ）被批准用于治疗成人斑块状银屑病，在两项 3 期临床试验中显示出了临床疗效。然而，HP/TAZ 的应用顺序尚未得到探索。本研究评估了在轻中度斑块状银屑病成人中，与先应用保湿剂后应用 HP/TAZ 相比，先应用 HP/TAZ 后应用含神经酰胺保湿剂的临床疗效。
16 名参与者随机分为两组，一组每天一次先应用 HP/TAZ 后应用保湿剂，另一组每天一次先应用保湿剂后应用 HP/TAZ，持续 12 周。评估了耐受性、安全性、疗效和生活质量终点。结果：无论应用顺序如何，所有时间点的研究者总体评估均显著改善（P≤0.003）。所有时间点的总皮肤病生活质量指数评分均显著改善（P≤0.003），瘙痒视觉模拟评分在第 4、8 和 12 周时显著改善（P<0.008）。有 3 名参与者经历了 4 次中度不良事件。2 名参与者报告瘙痒/刺激，当 HP/TAZ 先应用时更严重。
保湿剂的应用顺序并未降低 HP/TAZ 的疗效。在 HP/TAZ 之前应用保湿剂可能会减少用药部位不良反应的发生，最终提高耐受性，并支持在现实世界中的建议，即在应用 HP/TAZ 之前，而非之后，使用含神经酰胺的保湿剂，是一种安全有效的斑块状银屑病治疗选择。J 皮肤病药物杂志。2024；23（2）：50-53。doi：10.36849/JDD.7928。
