Parlier Y, Najman A, Lecomte D, Aegerter P
Gastroenterol Clin Biol. 1985 Dec;9(12):922-8.
We report the results of chemotherapy treatment in 82 patients presenting with primary digestive lymphoma and included in a study conducted between October 1977 and October 1985. There were 31 gastric lymphoma, 18 small intestinal lymphomas, and 19 with multiple involvement: 63 patients had had a surgical staging with total tumor resection in 15 cases. Nineteen patients with limited disease (ID and IID) were randomly assigned to either a 3-week chemotherapy regimen associated with whole abdominal radiotherapy or chemotherapy for 3 years. Twenty-seven stage IIID and thirty-six stage IV were treated with chemotherapy alone for 3 years. Low grade lymphomas (16 patients) received a cyclophosphamide, vincristine, prednisone association. Intermediate (56 patients) and high grade (10 patients) lymphomas received cyclophosphamide, vincristine, adriamycin, prednisone. The overall complete remission obtained was 63 p. 100 (51 patients) with 17 patients in relapse within 6 to 40 months. Overall survival was 46 p. 100 at 5 years. Survival was dependent on abdominal extension, histologic grade according to the new working formulation used for lymph-node lymphomas, initial localization (gastric lymphomas have the best survival) and achievement of complete remission. Chemotherapy is an effective treatment for primary digestive lymphomas. The role of surgery in the management of lymphomas has to be defined by further studies.
我们报告了1977年10月至1985年10月期间纳入一项研究的82例原发性消化淋巴瘤患者的化疗治疗结果。其中有31例胃淋巴瘤、18例小肠淋巴瘤和19例多部位受累患者：63例患者接受了手术分期，15例患者进行了肿瘤全切。19例局限性疾病（ID和IID）患者被随机分配接受为期3周的化疗方案联合全腹放疗或接受3年化疗。27例IIID期和36例IV期患者仅接受3年化疗。低度淋巴瘤（16例患者）接受环磷酰胺、长春新碱、泼尼松联合治疗。中度（56例患者）和高度（10例患者）淋巴瘤接受环磷酰胺、长春新碱、阿霉素、泼尼松治疗。总体完全缓解率为63%（51例患者），17例患者在6至40个月内复发。5年总生存率为46%。生存率取决于腹部受累范围、根据用于淋巴结淋巴瘤的新工作分类法确定的组织学分级、初始部位（胃淋巴瘤生存率最佳）以及是否实现完全缓解。化疗是原发性消化淋巴瘤的有效治疗方法。手术在淋巴瘤治疗中的作用有待进一步研究确定。
